Library Subscription: Guest
Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Role of Inflammation Amplifier-Induced Growth Factor Expression in the Development of Inflammatory Diseases

Volume 35, Issue 5, 2015, pp. 365-378
DOI: 10.1615/CritRevImmunol.v35.i5.20
Get accessGet access

ABSTRACT

Inflammation is a fundamental response induced by the immune system to protect the body against pathogens, tissue damage, and stress. At the same time, recent studies have suggested that chronically induced inflammation is involved in various human diseases and disorders. Thus, understanding the molecular mechanisms of chronic inflammation could provide therapeutic value. Many mediators such as cytokines or chemokines regulate inflammatory responses. Among them, interleukin(IL)-6 is a prominent cytokine that induces and maintains inflammatory reactions. It is expressed by activated CD4+ T cells and also non-immune cells such as fibroblasts and epithelial cells. We discovered an inflammation-induction machinery, the inflammation amplifier, which is activated by the simultaneous stimulation of nuclear factor-kappa B (NF-κB) and signal transducers and activator of transcription 3 (STAT3) via various cytokines like IL-17 and IL-6 in non-immune cells. Activation of the inflammation amplifier induces a synergistic increase of IL-6, inflammatory chemokines, and growth factors. Using genome-wide screening, we identified several growth factors as mediators of the inflammation amplifier. In this review, we highlight the role of growth factors in the inflammation mechanism with special attention on the inflammation amplifier.

CITED BY
  1. Tanaka Yuki, Arima Yasunobu, Kamimura Daisuke, Murakami Masaaki, The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels, Frontiers in Immunology, 8, 2017. Crossref

  2. NAKAGAWA Ikuma, MURAKAMI Masaaki, Inflammation amplifier and gateway reflex: The regulation of inflammation by neuroimmune interaction, Japanese Journal of Clinical Immunology, 40, 3, 2017. Crossref

  3. Ridgley Laura A., Anderson Amy E., Pratt Arthur G., What are the dominant cytokines in early rheumatoid arthritis?, Current Opinion in Rheumatology, 30, 2, 2018. Crossref

  4. Kamimura Daisuke, Ohki Takuto, Arima Yasunobu, Ota Mitsutoshi, Murakami Masaaki, Gateway reflex: Local neuroimmune interactions that regulate blood vessels, Neurochemistry International, 130, 2019. Crossref

  5. Marneros Alexander G., A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis, Journal of Investigative Dermatology, 139, 2, 2019. Crossref

  6. Kamimura Daisuke, Tanaka Yuki, Ohki Takuto, Murakami Masaaki, Gateway Reflex: A Neuro-Immune Crosstalk for Organ-Specific Disease Development, in Homeostasis - An Integrated Vision, 2019. Crossref

  7. Kamimura D., Murakami M., Neural stimulations regulate the infiltration of immune cells into the CNS , Journal of Internal Medicine, 286, 3, 2019. Crossref

  8. Stofkova Andrea, Murakami Masaaki, Neural activity regulates autoimmune diseases through the gateway reflex, Bioelectronic Medicine, 5, 1, 2019. Crossref

  9. Stofkova Andrea, Kamimura Daisuke, Ohki Takuto, Ota Mitsutoshi, Arima Yasunobu, Murakami Masaaki, Photopic light-mediated down-regulation of local α1A-adrenergic signaling protects blood-retina barrier in experimental autoimmune uveoretinitis, Scientific Reports, 9, 1, 2019. Crossref

  10. Xu Yichang, Gu Yong, Cai Feng, Xi Kun, Xin Tianwen, Tang Jincheng, Wu Liang, Wang Zhen, Wang Fei, Deng Lianfu, Pereira Catarina Leite, Sarmento Bruno, Cui Wenguo, Chen Liang, Metabolism Balance Regulation via Antagonist‐Functionalized Injectable Microsphere for Nucleus Pulposus Regeneration, Advanced Functional Materials, 30, 52, 2020. Crossref

  11. Stofkova Andrea, Zloh Miloslav, Andreanska Dominika, Fiserova Ivana, Kubovciak Jan, Hejda Jan, Kutilek Patrik, Murakami Masaaki, Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex, International Journal of Molecular Sciences, 23, 1, 2021. Crossref

  12. Shimoyama Shuhei, Nakagawa Ikuma, Jiang Jing-Jing, Matsumoto Isao, Chiorini John A, Hasegawa Yoshinori, Ohara Osamu, Hasebe Rie, Ota Mitsutoshi, Uchida Mona, Kamimura Daisuke, Hojyo Shintaro, Tanaka Yuki, Atsumi Tatsuya, Murakami Masaaki, Sjögren’s syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development, International Immunology, 33, 8, 2021. Crossref

  13. Takada Yusuke, Kamimura Daisuke, Jiang Jing-Jing, Higuchi Haruka, Iwami Daiki, Hotta Kiyohiko, Tanaka Yuki, Ota Mitsutoshi, Higuchi Madoka, Nishio Saori, Atsumi Tatsuya, Shinohara Nobuo, Matsuno Yoshihiro, Tsuji Takahiro, Tanabe Tatsu, Sasaki Hajime, Iwahara Naoya, Murakami Masaaki, Increased urinary exosomal SYT17 levels in chronic active antibody-mediated rejection after kidney transplantation via the IL-6 amplifier, International Immunology, 32, 10, 2020. Crossref

  14. Kamimura Daisuke, Ohki Takuto, Arima Yasunobu, Murakami Masaaki, Gateway reflex: neural activation-mediated immune cell gateways in the central nervous system, International Immunology, 30, 7, 2018. Crossref

  15. Higuchi Haruka, Kamimura Daisuke, Jiang Jing-Jing, Atsumi Toru, Iwami Daiki, Hotta Kiyohiko, Harada Hiroshi, Takada Yusuke, Kanno-Okada Hiromi, Hatanaka Kanako C, Tanaka Yuki, Shinohara Nobuo, Murakami Masaaki, Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation, International Immunology, 32, 5, 2020. Crossref

Forthcoming Articles

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain