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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i3.50
pages 249-267

Role of Type II NKT Cells in the Suppression of Graft-versus-Host Disease

Sae Jin Oh
Department of Pathology and Laboratory of Immune Regulation in the Department of Biomedical Sciences; Graduate School of Immunology, Seoul National University College of Medicine, Chongno-gu, 110-799, Seoul, South Korea
Ji Hyung Kim
Department of Pathology and Laboratory of Immune Regulation in the Department of Biomedical Sciences; Graduate School of Immunology, Seoul National University College of Medicine, Chongno-gu, 110-799, Seoul, South Korea
Chang Ki Min
Department of Internal Medicine Catholic University College of Medicine, Yeongdeungpo-gu, 150-713, Seoul, South Korea
Doo Hyun Chung
Department of Pathology and Laboratory of Immune Regulation in the Department of Biomedical Sciences, Seoul National University College of Medicine, Chongno-gu, 110-799, Seoul, South Korea

ABSTRACT

Natural killer T (NKT) cells, a distinct subset of T cells that recognize glycolipids on CD1d molecules, express both TCR and NK receptors and are critical in regulating various immune responses by modulating the Th1/Th2 balance. Upon activation, NKT cells produce large amounts of IL-4 and IFN-γ, resulting in the enhancement or inhibition of immune responses. Recent studies have shown that NKT cells are heterogeneous in terms of the expression of a specific Vα chain of TCR (Vα14-Jα18 in mice and Vα24-JαQ in humans) and reactivity against the glycolipid α-galactosylceramide (α-GalCer). Accordingly, NKT cells are classified into type I (invariant) and type II (non-invariant) cells in mice and humans. Although the functional roles of type I NKT cells are well characterized in various immune diseases, little is known regarding the function of type II NKT cells. Recent study has demonstrated that type II NKT cells in donor bone marrow play protective roles in graft-versus-host disease (GVHD), in which the complicated immunologic processes are involved. In this review, we discuss the pathogenesis of GVHD and the distinct functions of type II NKT cells in the development of GVHD.