Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Opposing Forces in Asthma: Regulation of Signaling Pathways by Kinases and Phosphatases
ABSTRACT
Allergic asthma is a chronic inflammatory disease that involves a sustained T-helper-2 (Th2) type immune response and the recruitment of inflammatory cells such as lymphocytes, mast cells, and eosinophils to the lung. The complex cellular interactions involved in this disease are dependent on cellular responses generated following the integration of environmental signals through the cell signaling pathways. Therefore, the elucidation of the biochemical cascades involved in cellular responses contributing to asthma development has been of great interest in this field. Much attention has been given to the activities of kinases, enzymes that catalyze the addition of a phosphate group to a protein, thus allowing them to modify the function of the target enzyme. This resulted in the identification of key kinases and various cellular processes involved in disease development. New investigations have also begun to unravel the importance of phosphatases, which catalyze the removal of a phosphate group from their target protein. Together, these studies reveal a signaling picture in allergic asthma that is far more complex than originally thought. Herein, we review critical mechanisms of asthma development and discuss how kinases and phosphatases are likely to regulate the development of disease through their effect on these various mechanisms.
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Lainé Dramane, Lucas Matthew, Lopez-Tapia Francisco, Lynch Stephen, Therapeutic Potential of Kinases in Asthma, in Medicinal Chemistry Approaches to Personalized Medicine, 2013. Crossref
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Xiong Youyi, Wang Junsong, Wu Feihua, Li Juan, Zhou Linfu, Kong Lingyi, Effects of (±)-praeruptorin A on airway inflammation, airway hyperresponsiveness and NF-κB signaling pathway in a mouse model of allergic airway disease, European Journal of Pharmacology, 683, 1-3, 2012. Crossref
-
Xiong Youyi, Wang Junsong, Yu Hao, Zhang Xiaolin, Miao Chenggui, Ma Shitang, The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma, Immunopharmacology and Immunotoxicology, 36, 5, 2014. Crossref
-
Xiong Youyi, Wang Junsong, Yu Hao, Zhang Xiaolin, Miao Chenggui, Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway disease, Immunopharmacology and Immunotoxicology, 37, 3, 2015. Crossref
-
Platt Michael P., Soler Zachary, Metson Ralph, Stankovic Konstantina M., Pathways Analysis of Molecular Markers in Chronic Sinusitis with Polyps, Otolaryngology–Head and Neck Surgery, 144, 5, 2011. Crossref
-
Matsuda Hiroyuki, Takeda Katsuyuki, Koya Toshiyuki, Okamoto Masakazu, Shiraishi Yoshiki, Miyahara Nobuaki, Dakhama Azzeddine, Matsuda Jennifer L., Gapin Laurent, Gelfand Erwin W., Plasticity of Invariant NKT Cell Regulation of Allergic Airway Disease Is Dependent on IFN-γ Production, The Journal of Immunology, 185, 1, 2010. Crossref
-
Bertics Paul J., Koziol-White Cynthia J, Gavala Monica L., Wiepz Gregory J., Signal Transduction, in Middleton's Allergy, 2014. Crossref