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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v27.i6.40
pages 539-546

Immune Mechanisms of Allergic Airway Disease: Regulation by Transcription Factors

Masakatsu Yamashita
Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan
Atsushi Onodera
Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan
Toshinori Nakayama
Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan

ABSTRACT

Allergic asthma is an airway inflammatory disease characterized by chronically increased expression of multiple inflammatory proteins, including cytokines, chemokines, adhesion molecules, enzymes, and receptors. Several transcription factors are known to play a crucial role in the pathogenesis of chronic inflammatory diseases such as asthma, including signal transducer and activator of transcription factors, nuclear factor-kappaB, nuclear factor of activated T cells, activator protein-1 family proteins, and Th2 cell—related transcription factors including GATA3, JunB, and c-Maf. Modulation of the activity of certain transcription factors has been shown to result in the inhibition of inflammation during asthma. Therefore, both agonists and inhibitors of transcription factors may be potential tools for the treatment of asthma. In this review, we summarize the current knowledge of the role of well-established transcription factors in asthma.


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