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Critical Reviews™ in Immunology

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ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Fungal Capsular Polysaccharide and T-Cell Suppression: The Hidden Nature of Poor Immunogenicity

Volume 27, Issue 6, 2007, pp. 547-557
DOI: 10.1615/CritRevImmunol.v27.i6.50
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Anna Vecchiarelli
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

ABSTRACT

Many capsular polysaccharide antigens are generally considered to be classic T-cell independent antigens that stimulate humoral response. This response is poor and short lived due to the absence of T-cell involvement. Recent emerging evidence suggests that fungal capsular polysaccharides may negatively affect T-cell response. This effect is indirectly mediated by antigen-presenting cells that sense microbial polysaccharides and manage T-cell response. This review will revisit the role of the cryptococcal capsular polysaccharide as a nonconventional regulator of natural and adaptive immune response, revealing the hidden nature of its poor immunogenicity and novel opportunities for the biomedical exploitation of this nontoxic compound.

CITED BY

  1. Khan Masood Alam, Aljarbou Ahmed, Khan Arif, Owais Mohammad, Immune stimulating and therapeutic potential of tuftsin-incorporated nystatin liposomes against Cryptococcus neoformans in leukopenic BALB/C mice, FEMS Immunology & Medical Microbiology, 66, 1, 2012. Crossref

  2. Guimarães Allan Jefferson, Frases Susana, Cordero Radamés J. B., Nimrichter Leonardo, Casadevall Arturo, Nosanchuk Joshua D., Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo, Cellular Microbiology, 12, 6, 2010. Crossref

  3. Gómez-López Alicia, Zaragoza Oscar, Rodríguez-Tudela Juan Luis, Cuenca-Estrella Manuel, Pharmacotherapy of yeast infections, Expert Opinion on Pharmacotherapy, 9, 16, 2008. Crossref

  4. Xia Rong, Hu Zhide, Sun Yi, Chen Sunxiao, Gu Mingli, Zhou Ye, Han Zhijun, Zhong Renqian, Deng Anmei, Wen Hai, Overexpression of β-Arrestin 2 in Peripheral Blood Mononuclear Cells of Patients With Cryptococcal Meningitis, Journal of Interferon & Cytokine Research, 30, 3, 2010. Crossref

  5. Nakouzi Antonio, Zhang Tong, Oscarson Stefan, Casadevall Arturo, The common Cryptococcus neoformans glucuronoxylomannan M2 motif elicits non-protective antibodies, Vaccine, 27, 27, 2009. Crossref

  6. Wolf Julie M., Rivera Johanna, Casadevall Arturo, Serum albumin disrupts Cryptococcus neoformans and Bacillus anthracis extracellular vesicles, Cellular Microbiology, 14, 5, 2012. Crossref

  7. Oliveira Débora L., Nimrichter Leonardo, Miranda Kildare, Frases Susana, Faull Kym F., Casadevall Arturo, Rodrigues Marcio L., Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan, Fungal Genetics and Biology, 46, 12, 2009. Crossref

  8. Mora Delio José, Fortunato Laila Rigolin, Andrade-Silva Leonardo Eurípedes, Ferreira-Paim Kennio, Rocha Ivonete Helena, Vasconcelos Rakel Rocha, Silva-Teixeira David Nascimento, Nascentes Gabriel Antonio Nogueira, Silva-Vergara Mario León, May Robin Charles, Cytokine Profiles at Admission Can Be Related to Outcome in AIDS Patients with Cryptococcal Meningitis, PLOS ONE, 10, 3, 2015. Crossref

  9. Zaragoza Oscar, García-Rodas Rocío, Nosanchuk Joshua D., Cuenca-Estrella Manuel, Rodríguez-Tudela Juan Luis, Casadevall Arturo, Mitchell Aaron P., Fungal Cell Gigantism during Mammalian Infection, PLoS Pathogens, 6, 6, 2010. Crossref

  10. Liedke Susie Coutinho, Miranda Daniel Zamith, Gomes Kamilla Xavier, Gonçalves Jorge Luis S., Frases Susana, Nosanchuk Joshua D., Rodrigues Marcio L., Nimrichter Leonardo, Peralta José Mauro, Guimarães Allan J., Characterization of the antifungal functions of a WGA-Fc (IgG2a) fusion protein binding to cell wall chitin oligomers, Scientific Reports, 7, 1, 2017. Crossref

  11. Jiang Ying-Kui, Wu Ji-Qin, Zhao Hua-Zhen, Wang Xuan, Wang Rui-Ying, Zhou Ling-Hong, Yip Ching-Wan, Huang Li-Ping, Cheng Jia-Hui, Chen Ya-Hong, Li Hua, Zhu Li-Ping, Weng Xin-Hua, Genetic influence of Toll-like receptors on non-HIV cryptococcal meningitis: An observational cohort study, EBioMedicine, 37, 2018. Crossref

  12. Gagliardi Maria Cristina, Teloni Raffaela, Mariotti Sabrina, Bromuro Carla, Chiani Paola, Romagnoli Giulia, Giannoni Federico, Torosantucci Antonella, Nisini Roberto, Endogenous PGE2 promotes the induction of human Th17 responses by fungal β-glucan, Journal of Leukocyte Biology, 88, 5, 2010. Crossref

  13. Hart K.A., Flaminio M.J.B.F., LeRoy B.E., Williams C.O., Dietrich U.M., Barton M.H., Successful Resolution of Cryptococcal Meningitis and Optic Neuritis in an Adult Horse with Oral Fluconazole, Journal of Veterinary Internal Medicine, 22, 6, 2008. Crossref

  14. Khan Muhammad Saeed, Zhang Xuewu, You Lijun, Fu Xiong, Abbasi Arshad Mehmood, Structure and Bioactivities of Fungal Polysaccharides, in Polysaccharides, 2014. Crossref

  15. Casadevall Arturo, Dadachova Ekaterina, Pirofski Liise-Anne, Vaccines and Antibody Therapies from Cryptococcus neoformans to Melanoma, in Cryptococcus, 2014. Crossref

  16. Perfect John R., Casadevall Arturo, The History of Cryptococcus and Cryptococcosis, in Cryptococcus, 2014. Crossref

  17. Fonseca Fernanda L., Frases Susana, Casadevall Arturo, Fischman-Gompertz Olga, Nimrichter Leonardo, Rodrigues Marcio L., Structural and functional properties of the Trichosporon asahii glucuronoxylomannan, Fungal Genetics and Biology, 46, 6-7, 2009. Crossref

  18. Piccioni M, Monari C, Bevilacqua S, Perito S, Bistoni F, Kozel T R, Vecchiarelli A, A critical role for FcgammaRIIB in up-regulation of Fas ligand induced by a microbial polysaccharide, Clinical and Experimental Immunology, 165, 2, 2011. Crossref

  19. Fonseca Fernanda L., Nohara Lilian L., Cordero Radames J. B., Frases Susana, Casadevall Arturo, Almeida Igor C., Nimrichter Leonardo, Rodrigues Marcio L., Immunomodulatory Effects of Serotype B Glucuronoxylomannan from Cryptococcus gattii Correlate with Polysaccharide Diameter , Infection and Immunity, 78, 9, 2010. Crossref

  20. Romani Luigina, Immunity to fungal infections, Nature Reviews Immunology, 11, 4, 2011. Crossref

  21. Lupo P., Chang Y. C., Kelsall B. L., Farber J. M., Pietrella D., Vecchiarelli A., Leon F., Kwon-Chung K. J., The Presence of Capsule in Cryptococcus neoformans Influences the Gene Expression Profile in Dendritic Cells during Interaction with the Fungus , Infection and Immunity, 76, 4, 2008. Crossref

  22. Summers Katie Lynn, Arfken Ann M., The Gut Mycobiome and Animal Health, in Gut Microbiota, Immunity, and Health in Production Animals, 4, 2022. Crossref

  23. Piccioni M., Monari C., Kenno S., Pericolini E., Gabrielli E., Pietrella D., Perito S., Bistoni F., Kozel T. R., Vecchiarelli A., Deepe G. S., A Purified Capsular Polysaccharide Markedly Inhibits Inflammatory Response during Endotoxic Shock, Infection and Immunity, 81, 1, 2013. Crossref

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