Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2015013844
pages 185-202

Understanding Lung Immunopathology Caused by the Human Metapneumovirus: Implications for Rational Vaccine Design

Christian E. Palavecino
Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
Pablo F. Cespedes
Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
Margarita K. Lay
Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
Claudia A. Riedel
Millennium Institute on Immunology and Immunotherapy, Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas y Facultad de Medicina, Universidad Andres Bello, Santiago, Chile
Alexis M. Kalergis
Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile; Departamento de Inmunologia, Facultad de Madicina
Susan M. Bueno
Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile; INSERM U1064, Nantes, France

ABSTRACT

Acute respiratory tract infections (ARTIs) are the major cause of child mortality worldwide. The human metapneumovirus (hMPV) is one of the leading causes of child hospitalizations due to pneumonia. The adaptive immune response generated by the host against hMPV is usually inefficient at protecting from reinfections, which is repeat throughout life, from childhood to old age. Despite considerable research efforts, to date there are no licensed vaccines to prevent respiratory disease caused by hMPV infection. In this article we review current vaccine strategies tested in animal models and the implication of such studies in understanding the different immune cell populations that contribute to hMPV clearance and the prevention and resolution of lung inflammation upon exposure to the virus.


Articles with similar content:

Chlamydial Infection of Immune Cells: Altered Function and Implications for Disease
Critical Reviews™ in Immunology, Vol.29, 2009, issue 4
Wilhelmina M. Huston, Peter Timms, Kenneth Beagley, Philip M. Hansbro
Brucella Virulence Mechanisms and Implications in Novel Vaccines and Drugs
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 1
Zeliang Chen, Guangjun Gao, Yufei Wang, Xingran Xu, Jie Xu
Autoimmune Etiology in Chronic Prostatitis Syndrome: An Advance in the Understanding of This Pathology
Critical Reviews™ in Immunology, Vol.27, 2007, issue 1
Virginia Elena Rivero, Ruben Dario Motrich, Clelia Maria Riera, Mariana Maccioni
Inflammation in Ischemic Brain Injury: Timing Is Important
Critical Reviews™ in Neurobiology, Vol.18, 2006, issue 1-2
Jasna Kriz
Chlamydia pneumoniae Infection and Inflammatory Diseases
Forum on Immunopathological Diseases and Therapeutics, Vol.7, 2016, issue 3-4
Timothy R. Crother, Rebecca A. Porritt