Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v21.i1-3.90
13 pages

Dendritic Cells in Cancer Immunotherapy

Matthias Gunzer
Department of Dermatology, University of Munster, Germany
Stephan Grabbe
Department of Dermatology, University of Munster, Germany

ABSTRACT

Antigen presentation is a critical regulatory element for the induction of cellular immune responses. Thus, one of the principal current goals of tumor immunotherapy is to control and enhance tumor antigen presentation. In this respect, dendritic cells (DC) are now being widely investigated as immunotherapeutic agents for the treatment of disseminated malignancies. At present, numerous ways to employ DCs for tumor immunotherapy are being tested, ranging from direct in situ expansion and activation of DCs to adoptive transfer of ex vivo generated DCs, and numerous techniques have been designed to optimize DC activation, tumor antigen delivery to DCs, and induction of tumor-specific, as well as helper immune responses, in vivo. However, the results of recent preclinical studies and the diversity of the clinical phase I trials that are currently underway indicate that little is still known about the exact mechanisms by which DCs modulate tumor immunity and pose the concern that premature clinical trials might not yield the desired results and might be harmful to, rather than promote, the concept of DC-based tumor immunotherapy. This review summarizes some of the current approaches to induce tumor immunity by DC-based vaccination and discusses their advantages and concerns.


Articles with similar content:

Therapeutic Dendritic Cell−Based Cancer Vaccines: The State of the Art
Critical Reviews™ in Immunology, Vol.33, 2013, issue 6
Marius M. Strioga, Valerijus Ostapenko, Daniel J. Powell Jr., Neringa T. Dobrovolskiene, Virgil E. J. C. Schijns, Thomas Felzmann, Jaroslav Michalek, Miroslava Matuskova

Gonorrhea: Immune Escape and Immunotherapeutic Strategies
Forum on Immunopathological Diseases and Therapeutics, Vol.7, 2016, issue 3-4
Ailina Heng Lao, Benjamin Bonavida

Peptide Mimotopes as Prototypic Templates of Broad-Spectrum Surrogates of Carbohydrate Antigens for Cancer Vaccination
Critical Reviews™ in Immunology, Vol.27, 2007, issue 3
Gajendra Raghava, Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi, Anastas Pashov

Central and Effector Memory CD4 and CD8 T-Cell Responses to Tumor-Associated Antigens
Critical Reviews™ in Immunology, Vol.32, 2012, issue 2
Stefano Caserta, Jessica Geraldine Borger, Rose Zamoyska

Clinical Translation of Peptide-Based Vaccine Trials: The HER-2/neu Model
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Keith L. Knutson, Douglas G. McNeel, Mary L. Disis, Donna Davis, Kathy Schiffman