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Critical Reviews™ in Immunology

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ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Victory and Defeat in the Induction of a Therapeutic Response through Vaccine Therapy for Human and Canine Brain Tumors: A Review of the State of the Art

Volume 34, Issue 5, 2014, pp. 399-432
DOI: 10.1615/CritRevImmunol.2014011577
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Michael R. Olin
Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, MN 55445
G Elizabeth Pluhar
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN. 55108
Brian M. Andersen
Department of Pediatrics. University of Minnesota, Minneapolis, MN 55445
Rob Shaver
Department of Pediatrics. University of Minnesota, Minneapolis, MN 55445
Nate N. Waldron
Department of Pediatrics. University of Minnesota, Minneapolis, MN 55445
Christopher L. Moertel
Department of Pediatrics. University of Minnesota, Minneapolis, MN 55445

ABSTRACT

Anti-tumor immunotherapy using tumor lysate−based vaccines has made great advances over recent decades. Cancer vaccines aim to elicit adaptive immune responses through various pathways by providing tumor and tumor-associated antigens with an immune stimulant or adjuvant. These anti-tumor vaccines are therefore developed as personalized treatments. Utilizing tumors as a source of vaccine antigens in immunotherapy has demonstrated promising results with minimal toxicity. However, to date, researchers have failed to overcome the overpowering immune suppressive effects within the tumor microenvironment. Immune suppression occurs naturally via multiple mechanisms. These mechanisms serve an important homeostatic role restoring a normal tissue microenvironment following an inflammatory response. Due to these suppressive mechanisms and the inherent heterogeneity of tumors, it is imperative to then elicit and maintain a specific tumoricidal response if vaccine therapy or some other combination of reagents is chosen. In this review, we focus on the historical use of tumors as a source of antigens to elicit a tumoricidal response and the limitations encountered that prevent greater success in immunotherapy. We describe the advantages and disadvantages of various vaccines and their ineffectiveness due to tumor-induced immune suppression.

KEY WORDS: Tumor lysate, immunosuppression, canine clioma model, CTLA-4
CITED BY

  1. LeBlanc Amy K., Mazcko Christina, Brown Diane E., Koehler Jennifer W., Miller Andrew D., Miller C. Ryan, Bentley R. Timothy, Packer Rebecca A., Breen Matthew, Boudreau C. Elizabeth, Levine Jonathan M., Simpson R. Mark, Halsey Charles, Kisseberth William, Rossmeisl John H., Dickinson Peter J., Fan Timothy M., Corps Kara, Aldape Kenneth, Puduvalli Vinay, Pluhar G. Elizabeth, Gilbert Mark R., Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients, Neuro-Oncology, 18, 9, 2016. Crossref

  2. Gardner Heather L., Londhe Priya, London Cheryl A., Leveraging dogs with spontaneous cancer to advance drug development, in Animal Models in Cancer Drug Discovery, 2019. Crossref

  3. Dow Steven, A Role for Dogs in Advancing Cancer Immunotherapy Research, Frontiers in Immunology, 10, 2020. Crossref

  4. LeBlanc Amy K., Mazcko Christina N., Improving human cancer therapy through the evaluation of pet dogs, Nature Reviews Cancer, 20, 12, 2020. Crossref

  5. Clemen Ramona, Bekeschus Sander, ROS Cocktails as an Adjuvant for Personalized Antitumor Vaccination?, Vaccines, 9, 5, 2021. Crossref

  6. Nemec Paige S., Holmes Jennifer C., Hess Paul R., Dog leukocyte antigen‐88*034:01 presents nonamer peptides from canine distemper virus hemagglutinin, large polymerase, and matrix proteins, HLA, 97, 5, 2021. Crossref

  7. Chen Li-Jeng, Hsu Tsai-Ching, Yeh Pei-Jung, Yow Jia Le, Chang Chia-Ling, Lin Cheng-Hui, Tzang Bor-Show, Differential Effects of Wedelia chinensis on Human Glioblastoma Multiforme Cells, Integrative Cancer Therapies, 20, 2021. Crossref

  8. Xiong Zhengming, Ampudia-Mesias Elisabet, Shaver Rob, Horbinski Craig M, Moertel Christopher L, Olin Michael R, Tumor-derived vaccines containing CD200 inhibit immune activation: implications for immunotherapy, Immunotherapy, 8, 9, 2016. Crossref

  9. Packer Rebecca A., Nervous System, in Veterinary Surgical Oncology, 2022. Crossref

  10. Sokolov Aleksandr V., Dostdar Samira A., Attwood Misty M., Krasilnikova Aleksandra A., Ilina Anastasia A., Nabieva Amina Sh., Lisitsyna Anna A., Chubarev Vladimir N., Tarasov Vadim V., Schiöth Helgi B., Gottesman Michael, Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies, Pharmacological Reviews, 73, 4, 2021. Crossref

  11. Withers Sita S., Sparger Ellen E., Boudreaux Bonnie, Mason Nicola J., Utilizing Microbes to Treat Naturally Occurring Cancer in Veterinary Species, Current Clinical Microbiology Reports, 6, 4, 2019. Crossref

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