Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2016017480
pages 99-129

IL10, A Tale of an Evolutionarily Conserved Cytokine across Vertebrates

M. Carla Piazzon
Cell Biology and Immunology Group, Wageningen University, The Netherlands; Fish Pathology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Consejo Superior de Investigaciones Cientificas, Castellon, Spain
George Lutfalla
CNRS/ Universite Montpellier, Montpellier, France
Maria Forlenza
Cell Biology and Immunology Group, Wageningen University, The Netherlands

ABSTRACT

IL10 was discovered in 1989, and since then it has been the subject of intense investigation, which has revealed its potent anti-inflammatory and regulatory activities in most immune processes during infection and disease. In 2003, the first non-mammalian IL10 sequence was identified in teleost fish, followed in 2004 by the chicken IL10 sequence. In this review, we summarize the work performed in non-mammalian vertebrates in which the IL10, IL10 receptors (IL10Rs), and their signaling components have been identified. We review the genomic organization, genes, and protein structure of IL10(Rs); we focus on studies providing a functional characterization of their biological activities. In addition, we describe the activities of viral IL10s identified in viruses infecting non-mammalian hosts. Altogether, our analysis reveals remarkable conservation of the anti-inflammatory and regulatory activities of (viral) IL10 across vertebrates, confirming the crucial role of IL10 throughout evolution. Interestingly, in some teleost fish, the presence of multiple copies of IL10(Rs) adds an additional degree of complexity. In fact, the evidence suggests that gene duplication does not necessarily imply functional redundancy, and leaves teleosts with additional possibilities to fine tune IL10 activities. Finally, we discuss the use of zebrafish (Danio rerio) as a complementary animal model for the study of IL10 activities in non-mammalian vertebrates.


Articles with similar content:

The Control of Meiotic Recombination in the Human Genome
Critical Reviews™ in Eukaryotic Gene Expression, Vol.28, 2018, issue 3
Mahmut Cerkez Ergoren
Variation Within the Human Killer Cell Immunoglobulin-Like Receptor ( KIR) Gene Family
Critical Reviews™ in Immunology, Vol.22, 2002, issue 5-6
Makoto Yawata, Nobuyo Yawata, Laurent Abi-Rached, Peter Parham
Insights into Monocyte-Driven Osteoclastogenesis and Its Link with Hematopoiesis: Regulatory Roles of PECAM-1 (CD31) and SHP-1
Critical Reviews™ in Immunology, Vol.30, 2010, issue 5
Joseph Madri, Yue Wu
The Granule Pathway of Programmed Cell Death
Critical Reviews™ in Immunology, Vol.25, 2005, issue 3
Philip G. Ashton-Rickardt
The Phylogeny of Alpha-Fetoprotein in Vertebrates: Survey of Biochemical and Physiological Data
Critical Reviews™ in Eukaryotic Gene Expression, Vol.5, 1995, issue 3-4
G.J. Mizejewski