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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v23.i56.30
18 pages

CD1d-Mediated Antigen Presentation to Natural Killer T (NKT) Cells

Randy R. Brutkiewicz
Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, Building R2, Room 302, 950 W. Walnut St., Indianapolis, IN 46202-5181
Yinling Lin
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208
Sungyoo Cho
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208
Yu Kyeong Hwang
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208
Venkataraman Sriram
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208
Tonya J. Roberts
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208

ABSTRACT

CD1d molecules are lipid antigen-presenting molecules. They are involved in presenting these antigens to a unique subpopulation of T cells called natural killer T (NKT) cells, which have the capacity to produce both T helper (Th) 1 and Th2 cytokines. Thus, it is possible that the antigens presented by CD1d and/or the level at which they are presented could have profound effects on the immunoregulation of autoimmune and infectious diseases, as well as cancer. Because of the ability of CD1d-binding ligands to modulate NKT cell responses, targeting CD1d-mediated antigen presentation as a novel approach for new therapies in these and other diseases holds great promise.


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