English
Русский
中文
日本語
Português
Spain
French
German
IF:
1.352
5-Year IF:
3.347
SJR:
0.657
SNIP:
0.55
CiteScore™:
2.19
ISSN Print: 1040-8401
Volumes:
|
Critical Reviews™ in Immunology
DOI: 10.1615/CritRevImmunol.v23.i56.30
18 pages CD1d-Mediated Antigen Presentation to Natural Killer T (NKT) Cells
Randy R. Brutkiewicz
Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, Building R2, Room 302, 950 W. Walnut St., Indianapolis, IN 46202-5181
Yinling Lin
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208
Sungyoo Cho
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208
Yu Kyeong Hwang
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208
Venkataraman Sriram
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208
Tonya J. Roberts
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208 ABSTRACTCD1d molecules are lipid antigen-presenting molecules. They are involved in presenting these antigens to a unique subpopulation of T cells called natural killer T (NKT) cells, which have the capacity to produce both T helper (Th) 1 and Th2 cytokines. Thus, it is possible that the antigens presented by CD1d and/or the level at which they are presented could have profound effects on the immunoregulation of autoimmune and infectious diseases, as well as cancer. Because of the ability of CD1d-binding ligands to modulate NKT cell responses, targeting CD1d-mediated antigen presentation as a novel approach for new therapies in these and other diseases holds great promise. Articles with similar content:
iNKT Cells: Innate Lymphocytes with a Diverse Response
Critical Reviews™ in Immunology, Vol.34, 2014, issue 1 Luis Graca, Marta Monteiro
Dendritic Cell-Derived Exosomes as Cell-Free Peptide-Based Vaccines
Critical Reviews™ in Immunology, Vol.25, 2005, issue 3 Julien Taieb, Nathalie Chaput, Laurence Zitvogel
Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression
Critical Reviews™ in Immunology, Vol.30, 2010, issue 5 Adam Mailloux, M. Rita I. Young
Antigen-Specific Tolerance in Immunotherapy of Th2-Associated Allergic Diseases
Critical Reviews™ in Immunology, Vol.33, 2013, issue 5 Paul J. Bryce, Charles B. Smarr, Stephen D. Miller
Neuropeptides and the Immune System: Focus on Dendritic Cells
Critical Reviews™ in Immunology, Vol.21, 2001, issue 6 Christian J. Wiederinann, Stefan Dunzendorfer |