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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v17.i3-4.40
pages 325-352

Regulation of the Function of Eosinophils and Basophils

Koichi Hirai
Department of Medicine and Physical Therapy, University of Tokyo, School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan
Misato Miyamasu
Department of Medicine and Physical Therapy, University of Tokyo, School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan
Toshiaki Takaishi
Department of Medicine and Physical Therapy, University of Tokyo, School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan
Yutaka Morita
Department of Medicine and Physical Therapy, University of Tokyo, School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan

ABSTRACT

Both eosinophils and basophils play active pathogenic roles in the inflammation associated with allergic disorders. Both types of cells share a majority of their cell surface structures, and because of these common surface molecules, both cells can be stimulated with a single ligand simultaneously. The growth of both types of cells is controlled by IL-3, GM-CSF, and IL-5. All three growth factors are also capable of priming both eosinophils and basophils for enhanced biological functions, such as increased mediator release and prolonged survival. Both cells express β2 integrins, and in contrast to neutrophils, they also express several β1 integrins. Ligation of these adhesion molecules also transduces the intracellular signal leading to regulation of the cellular functions. In this review, we briefly describe the effects of various ligands of surface receptors and several pharmacological compounds on the functions of human eosinophils and basophils.


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