Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.404 5-Year IF: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2017020025
pages 461-484

Emerging Roles of Granule Recycling in Mast Cell Plasticity and Homeostasis

Juan A. Flores
Dpto. Fisiologia Médica y Biofisica, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
Santiago Balseiro-Gómez
Dpto. Fisiologia Médica y Biofisica, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
Eva Ales
Dpto. Fisiologia Médica y Biofisica, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain

ABSTRACT

Secretory granules (SGs) of mast cells (MCs) release their contents to mediate many biological events and a variety of inflammatory diseases and have important protective roles in innate host defense and pathological functions in allergic reactions and anaphylaxis. There are two modes of MC degranulation during the release of granule contents to the extracellular environment. Anaphylactic degranulation (AND) after IgE-mediated activation is characterized by a rapid swelling and fusion of MC granules as well as abrupt mediators release. Piecemeal degranulation (PMD) is a slow and selective secretion of distinct granule mediators by vesicles shuttling from the granule compartment to the plasma membrane, and it is associated with several chronic diseases. Following degranulation, endocytosis is a fundamental biological event that is necessary to recycle granules and maintain the secretory response during repetitive stimulation. Rapid endocytosis through transient fusion (kiss-and-run, cavicapture and compound exo-endocytosis) has been described in MCs and can also result in the selective release of granule contents. In summary, several possible exo-endocytic mechanisms control the kinetics and magnitude of transmitter release, and each mechanism is associated with a different impact on granule replenishment, cell recovery, and consequently MC function under both normal and pathological conditions.


Articles with similar content:

Molecular Mechanisms of Chronic Intermittent Hypoxia and Hypertension
Critical Reviews™ in Biomedical Engineering, Vol.40, 2012, issue 4
Jag Sunderram, Ioannis P. Androulakis
Changes in the Activity of NO-Synthases and Oxidative Processes under 5-HT Receptor Activation in the Stomach and Large Intestine in Streptozotocin-Induced Diabetes Mellitus
International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 2
Oleksandr Ya. Sklyarov, O. Detsyk
Immune Functions of Serum Amyloid A
Critical Reviews™ in Immunology, Vol.32, 2012, issue 4
Kari K. Eklund, K. Niemi, P. T. Kovanen
The Effect of Neuraminidase Blocker on Gabazine-Induced Seizures in Rat Hippocampus
International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 4
Olena V. Isaeva, Dmytro S. Isaev, Platon G. Kostyuk, Alina V. Savrasova, Irina V. Lushnikova, Galina G. Skibo
Intracellular Pattern Recognition Receptors and Renal Ischemia
Critical Reviews™ in Immunology, Vol.31, 2011, issue 4
Dianne B. McKay