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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Interactions of Migrating T Lymphocytes, Inflammatory Mediators, and the Extracellular Matrix

Volume 15, Issue 3-4, 1995, pp. 271-283
DOI: 10.1615/CritRevImmunol.v15.i3-4.50
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ABSTRACT

Leukocytes are mobile units of the immune system. The process of leukocytes migration from blood vessels to inflamed tissues involves two major steps: (1) extravasation through the vessel wall and (2) movement through the underlying basement membrane and extracellular matrix (ECM). The ECM is a complex macromolecular mesh composed of proteoglycans and adhesive glycoproteins, such as collagen, laminin, and fibronectin, and serves as a supportive structure surrounding cells and can also provide co-stimulatory signals to immune cells. Hence, the basement membrane and the ECM play important roles as contexts in which biological processes take place, and therefore these moieties should be considered as microenvironment milieu in which extravasating cells function, communicate, and signal their messages; the outcome of which can result in the immunological eradication of hazardous elements. During migration, leukocytes continuously exchange information with the surrounding microenvironment. This cross-talk, which is also influenced by cytokines and chemokines, determines the type and the strength of the resulting immune response to foreign determinants. As suggested in the present article, these signals determine the response to a specific antigen and enable the migrating leukocytes to recognize any insult in their vicinity and to rapidly modify their activities.

CITED BY
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