IF:
1.352
5-Year IF:
3.347
SJR:
0.657
SNIP:
0.55
CiteScore™:
2.19
ISSN Print: 1040-8401
Volumes:
|
Critical Reviews™ in Immunology
DOI: 10.1615/CritRevImmunol.v15.i3-4.30
pages 235-253 T Cell Activation Pathways: B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles
Anette Gjorloff Wingren
The Wallenberg Laboratory, Department of Tumor Immunology, University of Lund, Box 7031, S-220 07, Lund, Sweden
Eduardo Parra
The Wallenberg Laboratory, Department of Tumor Immunology, University of Lund, Box 7031, S-220 07, Lund, Sweden
Mikael Varga
Pharmacia Immunology Oncology, Scheelevägen 22, S-223 63, Lund, Sweden
Terje Kalland
The Wallenberg Laboratory, Department of Tumor Immunology, University of Lund, Box 7031, S-220 07; Pharmacia Immunology Oncology, Scheelevägen 22, S-223 63, Lund, Sweden
Hans-Olov Sjogren
The Wallenberg Laboratory, Department of Tumor Immunology, University of Lund, Box 7031, S-220 07, Lund, Sweden
Gunnar Hedlund
The Wallenberg Laboratory, Department of Tumor Immunology, University of Lund, Box 7031, S-220 07; Pharmacia Immunology Oncology, Scheelevägen 22, S-223 63, Lund, Sweden
Mikael Dohlsten
The Wallenberg Laboratory, Department of Tumor Immunology, University of Lund, Box 7031, S-220 07; Pharmacia Immunology Oncology, Scheelevägen 22, S-223 63, Lund, Sweden ABSTRACTTwo signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to the T cell, while the second signal is provided by interaction with costimulatory ligands on APC. CD2, LFA-1, and CD28 are the major costimulatory and adhesive molecules on T cells and bind to the LFA-3, ICAM-1 and B7 ligands, respectively, on APC. LFA-3 plays a central role for naive and memory T helper cells during the early phase of an immune response. The LFA-3/CD2 pathway initiates strong antigen-independent cell adhesion, substantial expansion of naive T helper cells, and induction of large amounts of IFN-γ in memory cells. Articles with similar content:
T Cell Activation Pathways: B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles
Critical Reviews™ in Immunology, Vol.37, 2017, issue 2-6 Anette Gjorloff Wingren, Mikael Dohlsten, Hans-Olov Sjogren, Terje Kalland, Mikael Varga, Eduardo Parra, Gunnar Hedlund
Diverse Functional Activity of CD83+ Monocyte-Derived Dendritic Cells and the Implications for Cancer Vaccines
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3 Brian J. Czerniecki, Isabelle Bedrosian, Peter A. Cohen, Mark B. Faries, James G. Roros, Shuwen Xu
Role of the Glucocorticoid-Induced TNFR-Related Protein (GITR)-GITR Ligand Pathway in Innate and Adaptive Immunity
Critical Reviews™ in Immunology, Vol.30, 2010, issue 6 Miyuki Azuma
CD40 and Dendritic Cell Function
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2 Ranjeny Thomas, Brendan O'Sullivan
Costimulation Signals for Memory CD8+ T Cells During Viral Infections
Critical Reviews™ in Immunology, Vol.29, 2009, issue 6 Peter D. Katsikis, Alina C. Boesteanu, Priyanka A. Duttagupta |
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