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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Structure and Function of the CD7 Molecule

Volume 19, Issue 4, 1999, 18 pages
DOI: 10.1615/CritRevImmunol.v19.i4.40
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ABSTRACT

CD7 is a single-domain Ig superfamily molecule expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-l+ adult T-cell leukemia cells. Because of lack of identification of a natural ligand and lack of a monoclonal antibody against murine CD7, the in vivo functions of CD7 have until recently remained obscure. Recent studies in CD7-deficient mice have provided new insights into CD7 function, and demonstrated key roles for CD7 in regulating peripheral T and NK cell cytokine production and sensitivity to LPS-induced shock syndromes. This article reviews recent work on the expression, structure, and function of CD7, and discusses roles the CD7 molecule might play in T and NK cell development and function.

CITED BY
  1. Kosugi Nobuharu, Ebihara Yasuhiro, Nakahata Tatsutoshi, Saisho Hiromitsu, Asano Shigetaka, Tojo Arinobu, CD34+CD7+ Leukemic Progenitor Cells May Be Involved in Maintenance and Clonal Evolution of Chronic Myeloid Leukemia, Clinical Cancer Research, 11, 2, 2005. Crossref

  2. Hernandez Joseph D., Nguyen Julie T., He Jiale, Wang Wei, Ardman Blair, Green Jonathan M., Fukuda Minoru, Baum Linda G., Galectin-1 Binds Different CD43 Glycoforms to Cluster CD43 and Regulate T Cell Death, The Journal of Immunology, 177, 8, 2006. Crossref

  3. Pace Karen E., Hahn Hejin P., Pang Mabel, Nguyen Julie T., Baum Linda G., Cutting Edge: CD7 Delivers a Pro-Apoptotic Signal During Galectin-1-Induced T Cell Death, The Journal of Immunology, 165, 5, 2000. Crossref

  4. Assi Rita, Salman Huda, Harnessing the Potential of Chimeric Antigen Receptor T-Cell Therapy for the Treatment of T-Cell Malignancies: A Dare or Double Dare?, Cells, 11, 24, 2022. Crossref

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