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Critical Reviews™ in Immunology

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ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Chronic Lung Allograft Dysfunction: Immune Responses Induced by Circulating Exosomes with Lung-Associated Self-Antigens

Volume 39, Issue 2, 2019, pp. 123-134
DOI: 10.1615/CritRevImmunol.2019030635
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ABSTRACT

Exosomes, nanovesicles shown to regulate physiological processes in vivo, have been implicated in pathological conditions including cancer, autoimmune disease, infectious disease, neurodegenerative disease, and allograft rejection. Studies of lung transplant recipients with primary graft dysfunction, respiratory viral infection, and (acute) rejection have demonstrated circulating exosomes containing donor-mismatched human leukocyte antigen and lung-associated self-antigens, K-alpha 1 tubulin and collagen V, indicating that exosomes are originating from the transplanted organ. These circulating exosomes likely play a role in activating immune responses that lead to increased risk of chronic lung allograft dysfunction, as exosomes efficiently present their antigens to the immune system by all known pathways of antigen recognition (i.e., direct, indirect, and semidirect pathways). Here, we discuss exosome biogenesis, describe their contents, and address the mechanism of exosome-mediated activation of immune responses that lead to allograft rejection, especially after lung transplantation.

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CITED BY
  1. Arjuna Ashwini, Olson Michael T., Walia Rajat, Bremner Ross M., Smith Michael A., Mohanakumar Thalachallour, An update on current treatment strategies for managing bronchiolitis obliterans syndrome after lung transplantation, Expert Review of Respiratory Medicine, 15, 3, 2021. Crossref

  2. Frye C. Corbin, Bery Amit I., Kreisel Daniel, Kulkarni Hrishikesh S., Sterile inflammation in thoracic transplantation, Cellular and Molecular Life Sciences, 78, 2, 2021. Crossref

  3. Conrad Carol K., Hedlin Haley, Chin Hyunsook, Hayes Don, Heeger Peter S., Faro Albert, Goldfarb Samuel, Melicoff‐Portillo Ernestina, Thalachallour Mohanakumar, Odim Jonah, Schecter Marc, Storch Gregory A., Visner Gary A., Williams Nikki M., Kesler Karen, Danziger‐Isakov Lara, Sweet Stuart C., Auto‐inflammation and auto‐immunity pathways are associated with emergence of BOS in pediatric lung transplantation, Pediatric Transplantation, 26, 4, 2022. Crossref

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