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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v31.i2.30
pages 115-145

Expression and Immune Function of Tenascin-C

Irina A. Udalova
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, United Kingdom
Michaela Ruhmann
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, United Kingdom
Scott J.P. Thomson
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, United Kingdom
Kim S. Midwood
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, United Kingdom

ABSTRACT

Our immune system is designed to protect us from danger. Upon pathogen invasion and tissue injury, activation of both innate and adaptive immunity enables us to combat infection and to repair tissue damage. Tenascin-C is a large, extracellular matrix glycoprotein that has a very tightly controlled pattern of expression. Little or no tenascin-C is expressed in most healthy adult tissues; however, it is rapidly and transiently induced at sites of tissue injury and infection. Persistent tenascin-C expression is associated with pathologies such as chronic, non-healing wounds, autoimmune diseases, cancer, and fibrotic diseases. We discuss the myriad roles that this multifunctional molecule plays during the immune response, with a focus on how tissue levels of tenascin-C are regulated and the consequences of misregulated tenascin-C expression in immune regulated disease pathogenesis.