Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v23.i4.10
16 pages

Acquisition of MHC-Specific Receptors on Murine Natural Killer Cells

Linnea L. Veinotte
The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
Brian T. Wilhelm
The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
Dixie L. Mager
The Terry Fox Laboratory, British Columbia Cancer Agency; and Department of Medical Genetics and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
Fumio Takei
The Terry Fox Laboratory, British Columbia Cancer Agency; and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

ABSTRACT

NK cells in adult mice express two families of MHC class I–specific receptors, namely, Ly49 and CD94/NKG2. Co-expression of these receptors in various combinations generates diverse receptor repertoires. The expression of individual receptors is mostly stochastic and independent of each other. NK cells acquire the receptors as they develop from progenitors in the bone marrow in adult mice. In vivo as well as in vitro studies have shown that the acquisition of the receptors is ordered and regulated by the host MHC class I. Developing NK cells first acquire CD94/NKG2 and subsequently various Ly49 receptors in an ordered manner. Unlike adult NK cells, most fetal and neonatal NK cells express CD94/NKG2 but not Ly49. During the first several weeks after birth, NK cells expressing various Ly49 receptors slowly accumulate, while CD94/NKG2+ NK cells decrease to ~50% of the population. The acquisition of NK receptors following hematopoietic stem cell transplantation is also a slow and apparently preprogrammed process, mimicking the ontogeny, regardless of whether stem cells from fetal liver or adult bone marrow are used as donors. The regulation of the transcription of individual receptor genes is rather complex, since two promoters have been identified for the genes encoding Ly49 and CD94.


Articles with similar content:

Cytokine Synergy in Antigen-Independent Activation and Priming of Naive CD8+ T Lymphocytes
Critical Reviews™ in Immunology, Vol.29, 2009, issue 3
Julien Gagnon, Stephanie Dubois, Martin V. Richter, Subburaj Ilangumaran, Melissa Forand-Boulerice, Sheela Ramanathan
Signal Transduction via MHC Class I Molecules in Endothelial and Smooth Muscle Cells
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Elaine F. Reed
Interleukin 21: A Key Player in Lymphocyte Maturation
Critical Reviews™ in Immunology, Vol.24, 2004, issue 4
Jason Brady, Mark J. Smyth, Stephen L. Nutt, Yoshihiro Hayakawa
Expanding Role of T-Cell Costimulators in Regulatory T-Cell Function: Recent Advances in Accessory Molecules Expressed on Both Regulatory and Nonregulatory T Cells
Critical Reviews™ in Immunology, Vol.24, 2004, issue 4
Kazuo Sugamura, Ikuo Takeda, Naoto Ishii, Lishomwa C. Ndhlovu
Regulation of Immune Responses of the Intestinal Mucosa
Critical Reviews™ in Immunology, Vol.16, 1996, issue 3
Stephan R. Targan, Maria T. Abreu-Martin