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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i2.10
pages 95-107

Pathogen-Associated Molecular Pattern in Cancer Immunotherapy

Uwe Hobohm
University of Applied Sciences, Bioinformatics, Wiesenstrasse 14, D-35390 Giessen, Germany
John L. Stanford
Centre for Infectious Disease and International Health, Windeyer Institute for Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK
John M. Grange
Centre for Infectious Disease and International Health, Windeyer Institute for Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK

ABSTRACT

Observations from different research frontiers—epidemiological data, case studies on spontaneous regressions from cancer, clinical studies, tumor immunology—indicate that exposure by vaccination or infection to pathogen-associated molecular patterns (PAMP) can have beneficial effects on neoplastic diseases, both prophylactically and therapeutically. These effects have not yet been harnessed to their full extent for the prophylaxis and therapy of cancer. Here, we summarize clinical, epidemiological, and experimental data and discuss the role of PAMP in cancer therapy.