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Critical Reviews™ in Immunology

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ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Regulation Generation: The Suppressive Functions of Human Regulatory T Cells

Volume 32, Issue 1, 2012, pp. 65-79
DOI: 10.1615/CritRevImmunol.v32.i1.40
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ABSTRACT

Proper regulation of immune homeostasis is necessary to limit inflammation and prevent autoimmune and chronic inflammatory diseases. Many autoimmune diseases, such as psoriasis, are driven by vicious cycles of activated T cells that are unable to be suppressed by regulatory T cells. Effective suppression of auto-reactive T cells by regulatory T cells (Treg) is critical for the prevention of spontaneous autoimmune disease. Psoriatic Treg cells have been observed to a defect in their capacity to regulate, which clearly contributes to psoriasis pathogenesis. A challenge for translational research is the development of novel therapeutic interventions for autoimmune diseases that will result in durable remissions. Understanding the mechanism(s) of dysregulated T cell responses in autoimmune disease will allow for the development of future therapeutic strategies that may be employed to specifically target pathogenic, proinflammatory cells. Several reports have demonstrated a pathogenic role for Thl and Thl7 cells in psoriasis as well as other autoimmune diseases. Similarly, several laboratories have independently demonstrated functional defects in regulatory T cells isolated from patients with numerous divergent autoimmune diseases. One primary challenge of research in autoimmune diseases is therefore to restore the balance between chronic T cell activation and impairment of Treg suppressor mechanisms. To this end, it is critical to develop an understanding of the many suppressive mechanisms employed by Treg cells in hopes of developing more targeted therapeutic strategies for Treg-mediated autoimmune diseases.

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  3. Meyer Keith C., Immunity, Inflammation, and Aging, in Inflammation, Advancing Age and Nutrition, 2014. Crossref

  4. Baum Caitlin E, Mierzejewska Beata, Schroder Paul M, Khattar Mithun, Stepkowski Stanislaw, Optimizing the use of regulatory T cells in allotransplantation: recent advances and future perspectives, Expert Review of Clinical Immunology, 9, 12, 2013. Crossref

  5. Lin Zhijie, Wang Changrong, Xia Haizui, Liu Weiguang, Xiao Weiming, Qian Li, Jia Xiaoqin, Ding Yanbing, Ji Mingchun, Gong Weijuan, CD4+ NKG2D+T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1εtransgenic mice, Immunology, 141, 3, 2014. Crossref

  6. Juvet S. C., Whatcott A. G., Bushell A. R., Wood K. J., Harnessing Regulatory T Cells for Clinical Use in Transplantation: The End of the Beginning, American Journal of Transplantation, 14, 4, 2014. Crossref

  7. Kruser Jacqueline M., Meyer Keith C., Lung Infections and Aging, in Molecular Aspects of Aging, 2014. Crossref

  8. Kim Jaehwan, Krueger James G., The Immunopathogenesis of Psoriasis, Dermatologic Clinics, 33, 1, 2015. Crossref

  9. Kanemaru Hisashi, Jinnin Masatoshi, Asao Kae, Ichihara Asako, Makino Katsunari, Kajihara Ikko, Fujisawa Akihiko, Fukushima Satoshi, Ihn Hironobu, A case of psoriasis accompanied by arthritis after delivery, BioScience Trends, 8, 1, 2014. Crossref

  10. Zhang Bao-Xiang, Lyu Jun-Cheng, Liu Hai-Bo, Feng Dian-Qin, Zhang Dian-Cai, Bi Xing-Jie, Duan Zhi-Wu, Ding Gang, Attenuation of Peripheral Regulatory T-Cell Suppression of Skin-Homing CD8+T Cells in Atopic Dermatitis, Yonsei Medical Journal, 56, 1, 2015. Crossref

  11. Ferranti B., Armanino R., Becce C., L’importanza dei Toll-Like Receptors nei tessuti parodontali. Ruolo delle cellule del parodonto nell’attivazione dell’infiammazione locale in seguito ad aggressione batterica, Dental Cadmos, 82, 1, 2014. Crossref

  12. Chen Wei-Jun, Hu Xiao-Fan, Yan Min, Zhang Wen-Yong, Mao Xiao-Bo, Shu Yan-Wen, Human umbilical vein endothelial cells promote the inhibitory activation of CD4+CD25+Foxp3+ regulatory T cells via PD-L1, Atherosclerosis, 244, 2016. Crossref

  13. Guoping Peng, Wei Wu, Xiaoyan Liu, Fangping He, Zhongqin Chen, Benyan Luo, Characteristics of the peripheral T cell immune response of patients at different stages of vascular cognitive impairment, Immunology Letters, 168, 1, 2015. Crossref

  14. Hahn Susanne A., Bellinghausen Iris, Trinschek Bettina, Becker Christian, Translating Treg Therapy in Humanized Mice, Frontiers in Immunology, 6, 2015. Crossref

  15. Sudzius Gintaras, Mieliauskaite Diana, Siaurys Almantas, Viliene Rita, Butrimiene Irena, Characiejus Dainius, Dumalakiene Irena, Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients, Journal of Immunology Research, 2015, 2015. Crossref

  16. Trinschek Bettina, Luessi Felix, Gross Catharina, Wiendl Heinz, Jonuleit Helmut, Interferon-Beta Therapy of Multiple Sclerosis Patients Improves the Responsiveness of T Cells for Immune Suppression by Regulatory T Cells, International Journal of Molecular Sciences, 16, 7, 2015. Crossref

  17. Weitzmann M. Neale, The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis, Scientifica, 2013, 2013. Crossref

  18. Billich Andreas, Baumruker Thomas, Beerli Christian, Bigaud Marc, Bruns Christian, Calzascia Thomas, Isken Andrea, Kinzel Bernd, Loetscher Erika, Metzler Barbara, Mueller Matthias, Nuesslein-Hildesheim Barbara, Kleylein-Sohn Bernadette, Meuth Sven G., Partial Deficiency of Sphingosine-1-Phosphate Lyase Confers Protection in Experimental Autoimmune Encephalomyelitis, PLoS ONE, 8, 3, 2013. Crossref

  19. Meyer Keith C., Age-Associated Changes in Structure and Function of the Aging Human Lung, in Conn's Handbook of Models for Human Aging, 2018. Crossref

  20. Pankratz Susann, Bittner Stefan, Herrmann Alexander M., Schuhmann Michael K., Ruck Tobias, Meuth Sven G., Wiendl Heinz, Human CD4 + HLA‐G + regulatory T cells are potent suppressors of graft‐versus‐host disease in vivo , The FASEB Journal, 28, 8, 2014. Crossref

  21. Zhang Xiaolan, Li Jianping, Yu Yajie, Lian Peng, Gao Xinghua, Xu Yuanyuan, Geng Long, Shikonin Controls the Differentiation of CD4+CD25+ Regulatory T Cells by Inhibiting AKT/mTOR Pathway, Inflammation, 42, 4, 2019. Crossref

  22. Lowes Michelle A., Suárez-Fariñas Mayte, Krueger James G., Immunology of Psoriasis, Annual Review of Immunology, 32, 1, 2014. Crossref

  23. Dehbashi Moein, Hojati Zohreh, Motovali-bashi Majid, Ganjalikhany Mohamad Reza, Cho William C., Shimosaka Akihiro, Navabi Parnian, Ganjalikhani-Hakemi Mazdak, A Novel CAR Expressing NK Cell Targeting CD25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers, Frontiers in Oncology, 11, 2021. Crossref

  24. Cipriani P, Di Benedetto P, Liakouli V, Del Papa B, Di Padova M, Di Ianni M, Marrelli A, Alesse E, Giacomelli R, Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy, Clinical and Experimental Immunology, 173, 2, 2013. Crossref

  25. Grover Payal, Goel Peeyush N., Greene Mark I., Regulatory T Cells: Regulation of Identity and Function, Frontiers in Immunology, 12, 2021. Crossref

  26. Lee Jee H., Zou Le, Yang Runqing, Han Jihye, Wan Qingqing, Zhang Xian, El Baghdady Sarah, Roman Andrea, Elly Chris, Jin Hyung-seung, Park Yoon, Croft Michael, Liu Yun-Cai, The deubiquitinase CYLD controls protective immunity against helminth infection by regulation of Treg cell plasticity, Journal of Allergy and Clinical Immunology, 148, 1, 2021. Crossref

  27. Dehbashi Moein, Hojati Zohreh, Motovali-bashi Majid, Cho William C., Shimosaka Akihiro, Ganjalikhani-Hakemi Mazdak, Systems biology unravels the relationship of lncRNA OIP5-AS1 with CD25, Gene Reports, 24, 2021. Crossref

  28. Sennikova S. V., Toptygina A. P., Semikina E. L., Zakirov R. Sh., Akulova S. S., Mononuclear subsets and cytokine profile of venous and capillary blood in patients with psoriasis and healthy people, Medical Immunology (Russia), 23, 6, 2021. Crossref

  29. Pankratz Susann, Ruck Tobias, Meuth Sven G., Wiendl Heinz, CD4+HLA-G+ regulatory T cells: Molecular signature and pathophysiological relevance, Human Immunology, 77, 9, 2016. Crossref

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