Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2013007453
pages 283-306

Which Immune Cells Matter? The Immunopathogenesis of Multiple Sclerosis

Bieke Broux
Hasselt University, Biomedical Research Institute and transnationale Universiteit Limburg, School of Life Sciences, 3590 Diepenbeek, Belgium
Piet Stinissen
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium
Niels Hellings
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium

ABSTRACT

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is believed to be immune-mediated. While CD4+ T cells have been the main suspects for years, there is ample evidence that other immune cells (including those of the innate immune system) play a contributing or regulating role in this disease. After a general introduction, this review focuses on different immune cell subsets implicated in MS pathogenesis and on current and future possibilities to target them for therapeutic use.


Articles with similar content:

Antigen-Driven T-Cell Repertoire Selection
Critical Reviews™ in Immunology, Vol.25, 2005, issue 1
Koji Yasutomo, Yoichi Maekawa
Effect of Lymphodepletion on Donor T Cells and the Role of Recipient Cells Persisting after Cytotoxic Treatments in Cancer Immunotherapies
Critical Reviews™ in Immunology, Vol.37, 2017, issue 1
Toshiaki Kikuchi, Toshiyuki Koya, Masashi Arita, Miho Takahashi, Yu Saida, Satoshi Watanabe
Immunopathogenesis of Colitis-Associated Cancer in an Animal Model
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 3
Chuan-Xing Xiao, Bayasi Guleng, Jun-Lin Zhao
Regulation of Mast Cell Responses in Health and Disease
Critical Reviews™ in Immunology, Vol.31, 2011, issue 6
Michael A. Beaven, Alasdair M. Gilfillan
Antigen Delivery to Plasmacytoid Dendritic Cells -Induction of Tolerance and Immunity
Critical Reviews™ in Immunology, Vol.32, 2012, issue 6
Jakob Loschko , Anne Krug