Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.404 5-Year IF: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v25.i5.10
pages 343-360

Immune Functions of Proteinase 3

Shunji Sugawara
Division of Oral Immunology, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Sendai, Japan

ABSTRACT

The primary function of neutrophil-derived serine proteases, neutrophil elastase, cathepsin G, and proteinase 3 (PR3) are thought to be the degradation of extracellular proteins at sites of inflammation, but excessive, prolonged, or inappropriate proteolytic activity causes harmful effects in the body. Although there are strong structural similarities among these proteases, PR3 has unique properties in many respects. In particular, PR3 is a major target antigen of autoantibodies, anti-neutrophil cytoplasmic antibodies (ANCA). Recent findings also revealed that PR3 is critically involved in the regulation of immune function. This review discusses the expression of PR3 in nonhemopoietic cells and focuses on the immune functions of PR3 with respect to direct modulation of cell signaling by PR3, PR3-mediated cell activation, and the possible involvement of protease-activated receptors, modulation of the cytokine network, innate immunity and PR3, and recent findings about the generation and function of ANCA.


Articles with similar content:

Toll Like Receptor-2 Signaling in Mycobacterium Tuberculosis Infection−A Double-Edged Sword
Forum on Immunopathological Diseases and Therapeutics, Vol.6, 2015, issue 3-4
Sadhna Sharma, Monika Sharma
Function of Neurotrophic Factors Beyond the Nervous System: Inflammation and Autoimmune Demyelination
Critical Reviews™ in Immunology, Vol.29, 2009, issue 1
Ralf Linker, Ralf Gold, Fred Luhder
Role of Galectin-3 in the Initial Control of Leishmania Infection
Critical Reviews™ in Immunology, Vol.34, 2014, issue 2
Guillaume St-Pierre, Pampa Bhaumik, Isabelle Pelletier, Sachiko Sato
LPS-induced Cytokine Production in Human Monocytes and Macrophages
Critical Reviews™ in Immunology, Vol.31, 2011, issue 5
Matthew J. Sweet, Sunna Hauschildt, Holger Heine, Undine Meusch, Carina Klein, Dagmar Quandt, Manuela Rossol
The Role of Forkhead Box 1 (FOXO1) in the Immune System: Dendritic Cells, T Cells, B Cells, and Hematopoietic Stem Cells
Critical Reviews™ in Immunology, Vol.37, 2017, issue 1
Adriana Alicia Cabrera-Ortega, Daniel Feinberg, Carlos Rossa, Jr., Youde Liang, Dana T. Graves