Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v25.i1.20
pages 19-30

Properties of Glycolipid-Enriched Membrane Rafts in Antigen Presentation

William Rodgers
Molecular Immunogenetics Program, Oklahoma Medical Research Foundation; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Kenneth Smith
Molecular Immunogenetics Program, Oklahoma Medical Research Foundation, Oklahoma City, OK


Presentation of antigen to T cells represents one of the central events in the engagement of the immune system toward the defense of the host against pathogens. Accordingly, understanding the mechanisms by which antigen presentation occurs is critical toward our understanding the properties of host defense against foreign antigen, as well as insight into other features of the immune system, such as autoimmune disease. The entire antigen-presentation event is complex, and many features of it remain poorly understood. However, recent studies have provided evidence showing that glycolipid-enriched membrane rafts are important for efficient antigen presentation; the studies suggest that one such function of rafts is trafficking of antigen-MHC II complexes to the presentation site on the surface of the antigen-presenting cell. Here, we present a critical discussion of rafts and their proposed functions in antigen presentation. Emerging topics of rafts and antigen presentation that warrant further investigation are also highlighted.

Articles with similar content:

Toll-Like Receptor Family in Domestic Animal Species
Critical Reviews™ in Immunology, Vol.28, 2008, issue 6
Federica Riva, Lauretta Turin
Acquisition and Presentation of Tumor Antigens by Dendritic Cells
Critical Reviews™ in Immunology, Vol.35, 2015, issue 5
Guido Ferlazzo, Stefania Campana, Irene Bonaccorsi, Barbara Morandi
Mini-Review: The Non-Immune Functions of Toll-Like Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 1
Li Meng Shou, Li-Yao Ai, Man-Ting Chen, Yun Bei, Ying Song
Biological Function of HLA-DO (H2-O)
Critical Reviews™ in Immunology, Vol.34, 2014, issue 3
Xinjian Chen, Peter E. Jensen
The Inflammasome and Its Regulation
Critical Reviews™ in Immunology, Vol.34, 2014, issue 1
Hideki Hara, Kohsuke Tsuchiya