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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v25.i1.10
pages 1-18

Dendritic Epidermal T-Cell Activation

Leslie L. Sharp
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037
Julie M. Jameson
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037
Deborah A. Witherden
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037
H. Kiyomi Komori
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037
Wendy L. Havran
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037

ABSTRACT

Although γδ T cells compose a small proportion of lymphocytes in lymphoid compartments and peripheral blood, they are the major T-cell population present in epithelial tissues. However, the role played by γδ TCR expressing intraepithelial lymphocytes (IEL) has been enigmatic. The location of tissue-resident IEL suggests that they are important members of the first line of defense against insult for organs exposed to the environment, including the skin, gut, lungs, and reproductive system. Dendritic epidermal T cells (DETC) are the skin-resident γδIEL and serve as a model system for γδIEL in other locations. DETC have demonstrated importance in the modulation of immune responses, surveillance and repair of tissue, and resistance to infection. This work discusses recent developments in understanding DETC activation.


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