Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Latent Membrane Protein 1 and the B Lymphocyte−A Complex Relationship
ABSTRACT
The Epstein Barr Virus (EBV)-encoded latent membrane protein 1 (LMP1) exerts numerous impacts on the functions of B lymphocytes, the cell type in which EBV establishes long-term latent infections. LMP1 expression has been implicated in making important contributions to a variety of human malignancies, as well as to autoimmune diseases. EBV also infects other types of immune cells, as well as nasopharyngeal epithelium, and evidence suggests that LMP1 functions may differ among cell types. In this review, we focus upon LMP1 functions in B cells. A variety of in vitro and in vivo model systems have been used by numerous groups of investigators to probe the ways in which LMP1 alters B-cell biology and the molecular mechanisms by which it exerts these effects. Here, we present a current overview of LMP1-mediated signaling pathways and downstream functions in B cells, the in vivo outcomes of LMP1 expression in model systems and humans, and the associations between LMP1 and human disease.
-
Aki Daisuke, Zhang Wen, Liu Yun-Cai, The E3 ligase Itch in immune regulation and beyond, Immunological Reviews, 266, 1, 2015. Crossref
-
Lin Wai W., Hostager Bruce S., Bishop Gail A., TRAF3, ubiquitination, and B-lymphocyte regulation, Immunological Reviews, 266, 1, 2015. Crossref
-
Bishop Gail A., Stunz Laura L., Hostager Bruce S., TNF Receptor Superfamily Signaling Pathways in Immune Cells, in Encyclopedia of Immunobiology, 2016. Crossref
-
Bangalore-Prakash Pradeep, Stunz Laura L., Mambetsariev Nurbek, Whillock Amy L., Hostager Bruce S., Bishop Gail A., The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency, Blood Advances, 1, 27, 2017. Crossref
-
Zapata Juan M., Perez-Chacon Gema, Carr-Baena Pablo, Martinez-Forero Ivan, Azpilikueta Arantza, Otano Itziar, Melero Ignacio, CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs, Frontiers in Immunology, 9, 2018. Crossref
-
Wang Liang Wei, Wang Zhonghao, Ersing Ina, Nobre Luis, Guo Rui, Jiang Sizun, Trudeau Stephen, Zhao Bo, Weekes Michael P., Gewurz Benjamin E., Lagunoff Michael, Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival, PLOS Pathogens, 15, 9, 2019. Crossref
-
Wang Zifeng, Xie Jiajun, Yan Min, Wang Jing, Wang Xi, Zhang Jialiang, Zhang Yan, Li Pengfei, Lei Xinxing, Huang Qitao, Lin Suxia, Guo Xiang, Liu Quentin, Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma, Oncotarget, 7, 18, 2016. Crossref
-
Fingeroth Joyce, Epstein-Barr Virus, in Clinical Virology, 2016. Crossref
-
Munroe Melissa E., Anderson Jourdan R., Gross Timothy F., Stunz Laura L., Bishop Gail A., James Judith A., Epstein-Barr Functional Mimicry: Pathogenicity of Oncogenic Latent Membrane Protein-1 in Systemic Lupus Erythematosus and Autoimmunity, Frontiers in Immunology, 11, 2021. Crossref
-
Burton Eric M., Gewurz Benjamin E., Goodrum Felicia, Epstein–Barr virus oncoprotein–driven B cell metabolism remodeling, PLOS Pathogens, 18, 2, 2022. Crossref
-
Wang L, Ren J, Li G, Moorman J P, Yao Z Q, Ning S, LMP1 signaling pathway activates IRF4 in latent EBV infection and a positive circuit between PI3K and Src is required, Oncogene, 36, 16, 2017. Crossref
-
Burton Eric M., Voyer Jewel, Gewurz Benjamin E., Epstein–Barr virus latency programs dynamically sensitize B cells to ferroptosis, Proceedings of the National Academy of Sciences, 119, 11, 2022. Crossref