Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.9 5-Year IF: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Volume 37, 2020 Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2018021124
pages 521-553

Polymer-Based Drug Delivery Systems for Cancer

Ru Wen
Department of Chemistry, University of Georgia, Athens, GA
Afoma C. Umeano
Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, FL
Pingping Chen
University of Miami, Miller School of Medicine, Miami, FL
Ammad Ahmad Farooqi
Laboratory for Translational Oncology and Personalized Medicine, RLMC, Lahore, Pakistan


The standard treatment for metastatic cancer is generally a combination of chemotherapy, surgery, and radiotherapy. Since there are few specific chemotherapeutics approved by the US Food and Drug Administration, systemic chemotherapy is widely employed in the hopes of destroying rapidly dividing cancer cells before doing irreversible damage to the human body. Because of the nature of traditional chemotherapeutics, systemic treatment is associated with various side effects, such as nausea, dysphoria, vomiting, and pain, and long-term, irreversible damage to major organs, such as the kidney and heart. As life expectancy increases, so has the need for reliable cancer therapy that spares or prevents damage to functional healthy organs. One method is to precisely deliver drugs into specific tumor cells and tissues. Polymers have been characterized as favorable systems to deliver drugs with tunable pharmacokinetics, circulation times, biocompatibility, and biodegradability. Here, various types of polymers, modified as drug delivery systems for targeting cancer, and targeting behaviors of polymer-based carriers will be discussed.

KEY WORDS: therapy, apoptosis