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Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Targeted Gene Delivery: A Two-Pronged Approach

Volume 17, Issue 4, 2000, 48 pages
DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i4.30
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ABSTRACT

The success of gene therapy relies on the ability of gene delivery systems to selectively deliver therapeutic genes to a sufficient number of target cells yielding expression levels that impact the diseased state. The gene delivery systems can be divided into two classes: viral and non-viral (or plasmid DNA-based). The present gene delivery technology being used in climes today can be considered first generation, in that they possess the ability to transfect or infect target cells through their inherent chemical, biochemical, and molecular biological properties. Relying on these sole properties, however, limits therapeutic applications. Expansion of therapeutic applications or increased effectiveness of current therapies can be achieved by increasing the number of cells and cell types susceptible to gene transfer. This can be achieved through physical targeting and molecular biological targeting. Physical targeting relies on the attachment to the delivery vehicle of ligands that bind to cell surface receptors unique to the target cells. Molecular biological targeting refers to selective expression of the therapeutic gene by the target cell through the use of selective promoters. Selective expression can be further achieved by the use of expression systems controlled by extrinsic induction molecules. This review will describe in detail the advances that have been made in each of these areas of gene targeting.

CITED BY
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  8. Xia Aihua, Wu Qi, Liu Bokai, Lin Xianfu, Two-step synthesis of structure-diverse d-galactose conjugates and polymeric prodrugs of floxuridine via controllable regioselective enzymatic acylation of 3′- or 5′-OH group of floxuridine, Enzyme and Microbial Technology, 42, 5, 2008. Crossref

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  19. Chang Keejong, Qian Jin, Jiang MeiSheng, Liu Yi-Hsin, Wu Ming-Che, Chen Chi-Dar, Lai Chao-Kuen, Lo Hsin-Lung, Hsiao Chin-Ton, Brown Lucy, Bolen James, Huang Hsiao-I, Ho Pei-Yu, Shih Ping Yao, Yao Chen-Wen, Lin Wey-Jinq, Chen Chung-Hsi, Wu Fang-Yi, Lin Yi-Jen, Xu Jing, Wang Ken, Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer., BMC Biotechnology, 2, 1, 2002. Crossref

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