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Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.414 5-Year IF: 3.324 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i4.20
49 pages

Polysaccharides for Vascular Cell Targeting

Catherine Blondin
Current address: Institut Pasteur, Unite d'lmmuno-Allergie, 25 rue du Dr Roux, 75015 Paris, France
Isabelle Bataille
Laboratoire de Recherches sur les Macromolecules, Institut Galilee, Universite Paris 13, CNRS UMR 7540, IFREMER URM2, 99 Av. J.B. Clement, 93430 Villetaneuse, France
Didier Letourneur
Laboratoire de Recherches sur les Macromolecules, Institut Galilee, Universite Paris 13, CNRS UMR 7540, IFREMER URM2, 99 Av. J.B. Clement, 93430 Villetaneuse, France

ABSTRACT

Carbohydrate structures are involved in numerous biological activities such as inflammation, and cell adhesion/migration/proliferation. This gives the rationale for the design of vascular targeted drug delivery systems bearing sugar moieties. For the imaging and treatment of vascular diseases, an overview is presented with polysaccharides targeting vascular components. After a general description of the vasculature and the main blood components, a special emphasis is placed on carbohydrate-based molecules, such as heparin/heparan sulfate, and carbohydrate-binding proteins, such as selectins found in the vascular system. The methods using heparin and heparin analogs in delivery systems applied to vascular components are then described.