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Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

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Drug-Loaded PLGA Nanoparticles for Oral Administration: Fundamental Issues and Challenges Ahead

Volume 29, Issue 2, 2012, pp. 149-182
DOI: 10.1615/CritRevTherDrugCarrierSyst.v29.i2.20
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ABSTRACT

Drug-loaded polylactide-co-glycolide (PLGA) nanoparticles have been extensively studied and have a practical impact on drug delivery. Many PLGA-based nanoformulations have reached different stages of preclinical development; however, they present distinct challenges for researchers. This review discusses some of the challenges and issues involved in selecting drug and polymer combinations for encapsulation, aggregation of nanoparticles during characterization in in vitro studies, sterilization, and long-term stability of drug-loaded nanoparticles. We include recommendations to overcome these challenges.

CITED BY
  1. Dionísio Marita, Cordeiro Clara, Remuñán-López Carmen, Seijo Begoña, Rosa da Costa Ana M., Grenha Ana, Pullulan-based nanoparticles as carriers for transmucosal protein delivery, European Journal of Pharmaceutical Sciences, 50, 1, 2013. Crossref

  2. Agrawal Udita, Gupta Madhu, Vyas S. P., Capsaicin delivery into the skin with lipidic nanoparticles for the treatment of psoriasis, Artificial Cells, Nanomedicine, and Biotechnology, 43, 1, 2015. Crossref

  3. Lancelot Alexandre, Sierra Teresa, Serrano José Luis, Nanostructured liquid-crystalline particles for drug delivery, Expert Opinion on Drug Delivery, 11, 4, 2014. Crossref

  4. Luo Cong, Sun Jin, Du Yuqian, He Zhonggui, Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy, Journal of Controlled Release, 176, 2014. Crossref

  5. Steinbach Jill M., Seo Young-Eun, Saltzman W. Mark, Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization, Acta Biomaterialia, 30, 2016. Crossref

  6. Panta Prasamsha, Kim Da Yeon, Kwon Jin Seon, Son A Reum, Lee Kang Woo, Kim Moon Suk, Protein Drug-Loaded Polymeric Nanoparticles, Journal of Biomedical Science and Engineering, 07, 10, 2014. Crossref

  7. Rodrigues Susana, Cordeiro Clara, Seijo Begoña, Remuñán-López Carmen, Grenha Ana, Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation, Carbohydrate Polymers, 123, 2015. Crossref

  8. Wrona Magdalena, Cran Marlene J., Nerín Cristina, Bigger Stephen W., Development and characterisation of HPMC films containing PLA nanoparticles loaded with green tea extract for food packaging applications, Carbohydrate Polymers, 156, 2017. Crossref

  9. Srivastava Kamal D., Siefert Alyssa, Fahmy Tarek M., Caplan Michael J., Li Xiu-Min, Sampson Hugh A., Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy, Journal of Allergy and Clinical Immunology, 138, 2, 2016. Crossref

  10. Lee Byung Kook, Yun Yeonhee, Park Kinam, PLA micro- and nano-particles, Advanced Drug Delivery Reviews, 107, 2016. Crossref

  11. Costa-Gouveia Joana, Pancani Elisabetta, Jouny Samuel, Machelart Arnaud, Delorme Vincent, Salzano Giuseppina, Iantomasi Raffaella, Piveteau Catherine, Queval Christophe J., Song Ok-Ryul, Flipo Marion, Deprez Benoit, Saint-André Jean-Paul, Hureaux José, Majlessi Laleh, Willand Nicolas, Baulard Alain, Brodin Priscille, Gref Ruxandra, Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles, Scientific Reports, 7, 1, 2017. Crossref

  12. Wojtczak Edyta, Biedroń Tadeusz, Bednarek Melania, Hydrolytic stability of polylactide stereocomplex microparticles containing metal ions, Polymer Bulletin, 76, 3, 2019. Crossref

  13. Radhakrishnan Renju, Kamalasanan Kaladhar, Pharmaceutical perspectives of selection criteria and toxicity profiling of nanotheranostic agents, in Drug Delivery Nanosystems for Biomedical Applications, 2018. Crossref

  14. Yang Yifan, Yin Yunzhi, Zhang Jun, Zuo Tiantian, Liang Xiao, Li Jing, Shen Qi, Folate and Borneol Modified Bifunctional Nanoparticles for Enhanced Oral Absorption, Pharmaceutics, 10, 3, 2018. Crossref

  15. Palma Ernesto, Pasqua Antonella, Gagliardi Agnese, Britti Domenico, Fresta Massimo, Cosco Donato, Antileishmanial Activity of Amphotericin B-loaded-PLGA Nanoparticles: An Overview, Materials, 11, 7, 2018. Crossref

  16. Kirik Tuğçe, Kızılbey Kadriye, Rutin Loaded PLGA Nanoparticles; Synthesis by using Different Methods and Characterization, Journal of the Institute of Science and Technology, 2019. Crossref

  17. Wei Yanchun, Quan Li, Zhou Chao, Zhan Qiuqiang, Factors relating to the biodistribution & clearance of nanoparticles & their effects on in vivo application, Nanomedicine, 13, 12, 2018. Crossref

  18. Alshehri Sultan, Imam Syed Sarim, Rizwanullah Md, Fakhri Khalid Umar, Rizvi Mohd Moshahid Alam, Mahdi Wael, Kazi Mohsin, Effect of Chitosan Coating on PLGA Nanoparticles for Oral Delivery of Thymoquinone: In Vitro, Ex Vivo, and Cancer Cell Line Assessments, Coatings, 11, 1, 2020. Crossref

  19. Vibhavari R.J.A., Kumar Gautam, Rao Vanishree, Cheruku Sri Pragnya, Kumar Nitesh, Nano-pharmacokinetics: biodistribution and toxicology, in Nano-Pharmacokinetics and Theranostics, 2021. Crossref

  20. Zhang Yue, Jiang Ruining, Lei Lei, Yang Yingming, Hu Tao, Drug delivery systems for oral disease applications, Journal of Applied Oral Science, 30, 2022. Crossref

  21. Singh Neelu, Mishra Nidhi, Raza Kaisar, Parashar Poonam, PLGA Nanoparticles for Oral Delivery: Nephrotoxicity and Pharmacokinetic Studies, in Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems, 2022. Crossref

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