Library Subscription: Guest
Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Transdermal and Transmucosal Powdered Drug Delivery

Volume 16, Issue 4, 1999, pp. 331-384
DOI: 10.1615/CritRevTherDrugCarrierSyst.v16.i4.10
Get accessGet access

ABSTRACT

High-velocity powder injection is a promising new drag-delivery technique that provides needle- and pain-free delivery of traditional drags, drags from biotechnology such as proteins, peptides, and oligonucleotides as well as traditional and genetic vaccines. The energy of a transient helium gas jet accelerates fine drag particles of 20 μm−100 μm diameter to high velocities and delivers them into skin or mucosal sites. This review describes the configuration and operating principles of devices that accelerate the particles, the required properties of the particles, the characteristics of the target tissues, and features of the developmental test methods. Preclinical and clinical results that best characterize the technology and introduce its potential as a drug-delivery platform are presented.

CITED BY
  1. Mitragotri Samir, Immunization without needles, Nature Reviews Immunology, 5, 12, 2005. Crossref

  2. Chen Dexiang, Maa Yuh-Fun, Haynes Joel R, Needle-free epidermal powder immunization, Expert Review of Vaccines, 1, 3, 2002. Crossref

  3. Cleary Gary, Transdermal DDS, in Biomaterials Science, 2013. Crossref

  4. Schiffter Heiko, Condliffe Jamie, Vonhoff Sebastian, Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery, Journal of The Royal Society Interface, 7, suppl_4, 2010. Crossref

  5. Prausnitz Mark R., Analysis: Overcoming Skin's Barrier: The Search for Effective and User-Friendly Drug Delivery, Diabetes Technology & Therapeutics, 3, 2, 2001. Crossref

  6. Fatakdawala Hussain, Uhland Scott A., Hydrogen peroxide mediated transvaginal drug delivery, International Journal of Pharmaceutics, 409, 1-2, 2011. Crossref

  7. LIU Y., KENDALL M. A. F., NUMERICAL STUDY OF A TRANSIENT GAS AND PARTICLE FLOW IN A HIGH-SPEED NEEDLE-FREE BALLISTIC PARTICULATE VACCINE DELIVERY SYSTEM, Journal of Mechanics in Medicine and Biology, 04, 04, 2004. Crossref

  8. Brouillette M., Doré M., Hébert C., Spooner M.-F., Marchand S., Côté J., Gobeil F., Rivest M., Lafrance M., Talbot B. G., Moutquin J.-M., A new biolistic intradermal injector, Shock Waves, 26, 1, 2016. Crossref

  9. Weissmueller Nikolas T, Schiffter Heiko A, Pollard Andrew J, Intradermal powder immunization with protein-containing vaccines, Expert Review of Vaccines, 12, 6, 2013. Crossref

  10. Wheeler S., Mcginn B. J., Lucas M. L., Morrison J. D., Absorption of biologically active peptide hormones from the small intestine of rat, Acta Physiologica Scandinavica, 176, 3, 2002. Crossref

  11. Kendall Mark, Rishworth Stephen, Carter Fiona, Mitchell Thomas, Effects of Relative Humidity and Ambient Temperature on the Ballistic Delivery of Micro-Particles to Excised Porcine Skin, Journal of Investigative Dermatology, 122, 3, 2004. Crossref

  12. Ziegler A. S., Schluecker E., Reichel-Lesnianski P., Alt N., Lee G., Inactivation Effects on Proteins in a Needle-free Vaccine Injector, Engineering in Life Sciences, 6, 4, 2006. Crossref

  13. Park Jun-Bom, Noh Hyung-gon, Jung Jae-Hyuk, Kim Jung-Mi, Kang Chin-Yang, Enhanced transdermal delivery and optimization of nano-liposome preparation using hydrophilic drug, Journal of Pharmaceutical Investigation, 42, 2, 2012. Crossref

  14. Liu Yi, Kendall Mark A.F., Optimization of a jet-propelled particle injection system for the uniform transdermal delivery of drug/vaccine, Biotechnology and Bioengineering, 97, 5, 2007. Crossref

  15. Wang Ping M., Cornwell Megan, Hill James, Prausnitz Mark R., Precise Microinjection into Skin Using Hollow Microneedles, Journal of Investigative Dermatology, 126, 5, 2006. Crossref

  16. Kendall Mark, Needle-Free Ballistic Delivery of Powdered Immunotherapeutics to the Skin Using Supersonic Gas Flow, in Dermatologic, Cosmeceutic, and Cosmetic Development, 2007. Crossref

  17. Rochelle Christian, Lee Geoffrey, Dextran or Hydroxyethyl Starch in Sprayfreeze-Dried Trehalose/Mannitol Microparticles Intended as Ballistic Particulate Carriers for Proteins, Journal of Pharmaceutical Sciences, 96, 9, 2007. Crossref

  18. Lahm Katja, Lee Geoffrey, Penetration of Crystalline Powder Particles into Excised Human Skin Membranes and Model Gels from a Supersonic Powder Injector, Journal of Pharmaceutical Sciences, 95, 7, 2006. Crossref

  19. Schiffter Heiko, Lee Geoffrey, Single-Droplet Evaporation Kinetics and Particle Formation in an Acoustic Levitator. Part 1: Evaporation of Water Microdroplets Assessed Using Boundary-Layer and Acoustic Levitation Theories, Journal of Pharmaceutical Sciences, 96, 9, 2007. Crossref

  20. Zhang Dongwei, Das Diganta B., Rielly Chris D., An Experimental Study of Microneedle-Assisted Microparticle Delivery, Journal of Pharmaceutical Sciences, 102, 10, 2013. Crossref

  21. Mitragotri Samir, Mechanical Disruption of Skin Barrier for Vaccine Delivery, Drug Delivery System, 27, 3, 2012. Crossref

  22. Schiffter Heiko, Lee Geoffrey, Single-Droplet Evaporation Kinetics and Particle Formation in an Acoustic Levitator. Part 2: Drying Kinetics and Particle Formation From Microdroplets of Aqueous Mannitol, Trehalose, or Catalase, Journal of Pharmaceutical Sciences, 96, 9, 2007. Crossref

  23. Ziegler Andreas S., Needle-Free Delivery of Powdered Protein Vaccines: A New and Rapidly Developing Technique, Journal of Pharmaceutical Innovation, 3, 3, 2008. Crossref

  24. Uchida Masaki, Natsume Hideshi, Kobayashi Daisuke, Sugibayashi Kenji, Morimoto Yasunori, Effects of Particle Size, Helium Gas Pressure and Microparticle Dose on the Plasma Concentration of Indomethacin after Bombardment of Indomethacin-Loaded Poly-L-Lactic Acid Microspheres Using a Helios Gun System., Biological and Pharmaceutical Bulletin, 25, 5, 2002. Crossref

  25. Kayser Oliver, Kiderlen Albrecht F., Virus-free Gene Transfer Systems in Somatic Gene Therapy, in Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2006. Crossref

  26. Liu Yi, Quantitative Evaluation of the Skin Heat Transfer Characteristics Subjected to a Transient High-speed Helium Gas Impingement, Journal of Biological Sciences, 6, 2, 2006. Crossref

  27. Schuetz Yannic B, Naik Aarti, Guy Richard H, Kalia Yogeshvar N, Emerging strategies for the transdermal delivery of peptide and protein drugs, Expert Opinion on Drug Delivery, 2, 3, 2005. Crossref

  28. Guha R. A., Shear N. H., Papini M., Ballistic Impact of Single Particles Into Gelatin: Experiments and Modeling With Application to Transdermal Pharmaceutical Delivery, Journal of Biomechanical Engineering, 132, 10, 2010. Crossref

  29. Condliffe Jamie, Schiffter Heiko A., Cleveland Robin O., Coussios Constantin-C., An acoustic microscopy technique to assess particle size and distribution following needle-free injection, The Journal of the Acoustical Society of America, 127, 4, 2010. Crossref

  30. Li Chun-yu, Wang Zhe-wei, Tu Can, Wang Jia-bo, Jiang Bing-qian, Li Qi, Zeng Ling-na, Ma Zhi-jie, Zhang Ping, Zhao Yan-ling, Zhang Ya-ming, Yan Dan, Tan Rui, Xiao Xiao-he, Needle-free injection of insulin powder: delivery efficiency and skin irritation assessment, Journal of Zhejiang University SCIENCE B, 15, 10, 2014. Crossref

  31. Cevc Gregor, Lipid vesicles and other colloids as drug carriers on the skin, Advanced Drug Delivery Reviews, 56, 5, 2004. Crossref

  32. Torin Huzil J., Sivaloganathan Siv, Kohandel Mohammad, Foldvari Marianna, Drug delivery through the skin: molecular simulations of barrier lipids to design more effective noninvasive dermal and transdermal delivery systems for small molecules, biologics, and cosmetics, WIREs Nanomedicine and Nanobiotechnology, 3, 5, 2011. Crossref

  33. Cleland Jeffrey L, Daugherty Ann, Mrsny Randall, Emerging protein delivery methods, Current Opinion in Biotechnology, 12, 2, 2001. Crossref

  34. Mitchell Thomas J, Kendall Mark AF, Bellhouse Brian J, A ballistic study of micro-particle penetration to the oral mucosa, International Journal of Impact Engineering, 28, 6, 2003. Crossref

  35. Arora Anubhav, Prausnitz Mark R., Mitragotri Samir, Micro-scale devices for transdermal drug delivery, International Journal of Pharmaceutics, 364, 2, 2008. Crossref

  36. Brown Marc B., Martin Gary P., Jones Stuart A., Akomeah Franklin K., Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects, Drug Delivery, 13, 3, 2006. Crossref

  37. Barry B.W, Novel mechanisms and devices to enable successful transdermal drug delivery, European Journal of Pharmaceutical Sciences, 14, 2, 2001. Crossref

  38. Hogan Nora C, Taberner Andrew J, Jones Lynette A, Hunter Ian W, Needle-free delivery of macromolecules through the skin using controllable jet injectors, Expert Opinion on Drug Delivery, 12, 10, 2015. Crossref

  39. Elshafeey Ahmed H., Hamza Yassin E., Amin Soad Y., Zia Hossein, In vitro transdermal permeation of fenoterol hydrobromide, Journal of Advanced Research, 3, 2, 2012. Crossref

  40. Liu Yi, Costigan George, Bellhouse Brian J., Performance studies of a conical nozzle designed for the macromolecular skin delivery, Journal of Drug Targeting, 16, 3, 2008. Crossref

  41. Kendall Mark, Mitchell Thomas J., Costigan George, Armitage Mark, Lenzo Jason C., Thomas Jennifer A., von Garnier Christophe, Zosky Graeme R., Turner Debra J., Stumbles Phil A., Sly Peter D., Holt Patrick G., Thomas Wayne R., Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery, Journal of Allergy and Clinical Immunology, 117, 2, 2006. Crossref

  42. Kendall M.A.F., Carter F.V., Mitchell T.J., Bellhouse B.J., Comparison of the transdermal ballistic delivery of micro-particles into human and porcine skin, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 3, 2001. Crossref

  43. Iftekhar Rasel M.A., Kim H.D., A computational study of drug particle delivery through a shock tube, Journal of Drug Delivery Science and Technology, 24, 4, 2014. Crossref

  44. Kendall M.A.F., Wrighton Smith P.J., Bellhouse B.J., Transdermal ballistic delivery of micro-particles: investigation into skin penetration, Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Cat. No.00CH37143), 3, 2000. Crossref

  45. Singh Thakur Raghu Raj, Gujral Chirag, Microporation for Enhanced Transdermal Drug Delivery, in Novel Delivery Systems for Transdermal and Intradermal Drug Delivery, 2015. Crossref

  46. Naik Aarti, Kalia Yogeshvar N., Guy Richard H., Transdermal drug delivery: overcoming the skin’s barrier function, Pharmaceutical Science & Technology Today, 3, 9, 2000. Crossref

  47. McGinn B.J., Morrison J.D., Investigations into the absorption of insulin and insulin derivatives from the small intestine of the anaesthetised rat, Journal of Controlled Release, 232, 2016. Crossref

  48. Front Matter, in A Guide to Pharmaceutical Particulate Science, 2003. Crossref

  49. Milewski Mikolaj, Brogden Nicole K, Stinchcomb Audra L, Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin, Expert Opinion on Drug Delivery, 7, 5, 2010. Crossref

  50. Hadgraft Jonathan, Lane Majella E., Drug crystallization – implications for topical and transdermal delivery, Expert Opinion on Drug Delivery, 13, 6, 2016. Crossref

  51. Battula N., Menezes V., Bhalekar S., Bhalekar S.H., Nejad S.M., Hosseini H., Impulse-powered needle-free syringe for vaccine/drug injection, Technology and Health Care, 25, 6, 2017. Crossref

  52. Weissmueller Nikolas T., Marsay Leanne, Schiffter Heiko A., Carlisle Robert C., Rollier Christine S., Prud’homme Robert K., Pollard Andrew J., Miyaji Eliane N., Alternative vaccine administration by powder injection: Needle-free dermal delivery of the glycoconjugate meningococcal group Y vaccine, PLOS ONE, 12, 8, 2017. Crossref

  53. Kendall M. A. F., Quinlan N. J., Thorpe S. J., Ainsworth R. W., Bellhouse B. J., Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery, Experiments in Fluids, 37, 1, 2004. Crossref

  54. Marrion M. C., Kendall M. A. F., Liu Y., The gas-dynamic effects of a hemisphere-cylinder obstacle in a shock-tube driver, Experiments in Fluids, 38, 3, 2005. Crossref

  55. Prausnitz Mark R., Mitragotri Samir, Langer Robert, Current status and future potential of transdermal drug delivery, Nature Reviews Drug Discovery, 3, 2, 2004. Crossref

  56. Kayser Oliver, Bioanalytik und biopharmazeutische Grundlagen in der Produktentwicklung, in Grundwissen Pharmazeutische Biotechnologie, 2002. Crossref

  57. Kayser Oliver, Weiterführende Literatur und Internetlinks, in Grundwissen Pharmazeutische Biotechnologie, 2002. Crossref

  58. Brouillette M., A New Biolistic Intradermal Injector Based on a Miniature Shock Tube, in 29th International Symposium on Shock Waves 2, 2015. Crossref

  59. Brown Marc B., Traynor Matthew J., Martin Gary P., Akomeah Franklin K., Transdermal Drug Delivery Systems: Skin Perturbation Devices, in Drug Delivery Systems, 437, 2008. Crossref

  60. Todo Hiroaki, Sugibayashi Kenji, Transdermal delivery of mal-absorbable drugs with chemical- and physical enhancement methods, Drug Delivery System, 27, 3, 2012. Crossref

  61. Ichikawa Hideki, Less Invasive, Locally Injectable Drug Delivery Systems Fabricated by Nanodispersion Spray-Coating Technology, Hosokawa Powder Technology Foundation ANNUAL REPORT, 15, 2007. Crossref

  62. Kendall Mark A. F., Needle-Free Vaccine Injection, in Drug Delivery, 197, 2010. Crossref

  63. Mutukuri Tarun Tejasvi, Wilson Nathan E., Taylor Lynne S., Topp Elizabeth M., Zhou Qi Tony, Effects of drying method and excipient on the structure and physical stability of protein solids: Freeze drying vs. spray freeze drying, International Journal of Pharmaceutics, 594, 2021. Crossref

  64. Jahan , Archie , Shoyaib , Kabir , Cheung , Recent Approaches for Solid Dose Vaccine Delivery, Scientia Pharmaceutica, 87, 4, 2019. Crossref

  65. Paudel Kalpana S, Milewski Mikolaj, Swadley Courtney L, Brogden Nicole K, Ghosh Priyanka, Stinchcomb Audra L, Challenges and opportunities in dermal/transdermal delivery, Therapeutic Delivery, 1, 1, 2010. Crossref

  66. Trimzi Mojiz Abbas, Ham Young-Bog, A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery, Pharmaceutics, 13, 11, 2021. Crossref

  67. Mutukuri Tarun Tejasvi, Maa Yuh-Fun, Gikanga Benson, Sakhnovsky Robert, Zhou Qi Tony, Electrostatic spray drying for monoclonal antibody formulation, International Journal of Pharmaceutics, 607, 2021. Crossref

  68. Meng Shuangshuang, Taddei Lorenzo, Al-Khalil Monzer, Roth Sebastien, SPH-based simulation of micro-impacts in human-tissue surrogate: A preliminary study on multilayered structure, Mechanics of Advanced Materials and Structures, 2021. Crossref

  69. Transdermal Drug Delivery, in Microneedle‐Mediated Transdermal and Intradermal Drug Delivery, 2012. Crossref

  70. Wang Wei, Xue Weiwei, Wu Shufan, Mu Zhongcheng, Yi Jiyuan, Tang Andrew J., High-Speed Micro-Particle Motion Monitoring Based on Continuous Single-Frame Multi-Exposure Technology, Materials, 15, 11, 2022. Crossref

  71. Kis Elsa E., Winter Gerhard, Myschik Julia, Devices for intradermal vaccination, Vaccine, 30, 3, 2012. Crossref

  72. Liu Y, Kendall M A F, Numerical simulation of heat transfer from a transonic jet impinging on skin for needle-free powdered drug and vaccine delivery, Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 218, 11, 2004. Crossref

  73. McCaffrey Joanne, Donnelly Ryan F., McCarthy Helen O., Microneedles: an innovative platform for gene delivery, Drug Delivery and Translational Research, 5, 4, 2015. Crossref

  74. Mutukuri Tarun Tejasvi, Darwish Ahmad, Strongrich Andrew David, Peroulis Dimitrios, Alexeenko Alina, Zhou Qi (Tony), Radio Frequency - Assisted Ultrasonic Spray Freeze Drying for Pharmaceutical Protein Solids, Journal of Pharmaceutical Sciences, 112, 1, 2023. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain