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Critical Reviews™ in Therapeutic Drug Carrier Systems

Impact factor: 5.367

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v21.i6.20
44 pages

Osmotic Pumps in Drug Delivery

Rajan K. Verma
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab; and Ranbaxy Research Laboratories, Gurgaon, Haryana, India
Sachin Arora
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab; and Ranbaxy Research Laboratories, Gurgaon, Haryana, India
Sanjay Garg
School of Pharmacy, The University of Auckland, Private Bag 92-019, Auckland, New Zealand; and Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India

ABSTRACT

In recent years, novel drug delivery systems (NDDS) have been recognized as an attractive niche for the pharmaceutical and health industry. Among various NDDS, osmotic pumps have matured from their use with laboratory animals to the most reliable controlled release systems for humans. Osmotically controlled drug delivery systems use osmotic pressure for controlled delivery of active agent(s). Drug delivery from these systems, to a large extent, is independent of the physiological factors of the gastrointestinal tract. Because of their unique advantages over other types of dosage forms, osmotic pumps form a class of their own among the various drug delivery technologies, and a variety of products based on this technology are available on the market. This article is a review of different types of osmotic pumps and their role in drug delivery.