Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems

Impact factor: 5.367

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2013005684
pages 277-291

Particulate Pulmonary Delivery Systems Containing Anti-Tuberculosis Agents

Anuradha Gupta
CSIR Central Drug Research Institute, Lucknow 226001, India
Sanketkumar M. Pandya
CSIR Central Drug Research Institute, Lucknow 226001, India
Imran Mohammad
CSIR Central Drug Research Institute, Lucknow 226001, India
Atul Kumar Agrawal
CSIR Central Drug Research Institute, Lucknow 226001, India
Mradul Mohan
CSIR Central Drug Research Institute, Lucknow 226001, India
Amit Misra
CSIR Central Drug Research Institute, Lucknow 226001, India

ABSTRACT

There is renewed interest in delivering anti-tuberculosis (TB) drugs to the lungs by inhalation. Several groups have investigated particulate pulmonary drug delivery formulations containing anti-TB agents, prepared using a variety of design approaches and processes. This review summarizes trends that indicate feasibility and translation of research efforts aimed at developing inhaled therapies for TB. Whereas formulations intended for reconstitution as solutions prior to nebulization can be produced with relative ease, particle engineering for powder formulations is more specialized. Spray drying and emulsion methods used to prepare particulate pulmonary delivery systems of anti-TB agents are compared. Pharmaceutical characterization is outlined. Administration of repeated inhalations to laboratory animals, especially under Animal Biosafety Level-3 (ABSL-3) containment as required for TB research, is another major challenge. Techniques employed by different groups are reviewed in the context of suitability for drug delivery and amenability towards use in ABSL-3 settings. It is concluded that spray drying is suitable for production of inhalable particles, rigorous physicochemical characterization is necessary for developing inhaled therapies as drug products, and pulmonary delivery of formulations containing anti-TB drugs to animals infected with Mycobacterium tuberculosis can best be carried out using handheld devices.