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Critical Reviews™ in Therapeutic Drug Carrier Systems

Impact factor: 3.174

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i2.10
pages 107-150

Hydrogels for Pharmaceutical and Biomedical Applications

N. Kashyap
Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research, Punjab, India
N. Kumar
Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research, Punjab, India
M. N. V. Ravi Kumar
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India

ABSTRACT

Hydrogels are crosslinked hydrophilic polymer structures that can imbibe large amounts of water or biological fluids. Hydrogels are one of the upcoming classes of polymer-based systems that embrace numerous biomedical and pharmaceutical applications. This review discusses various parameters of hydrogels such as surface properties, water content and swelling behavior, effect of nature of polymer, ionic content, and thermodynamics, all of which can influence the biomedical usage of hydrogels. Meanwhile, intelligent or environment-sensitive hydrogels and bioadhesive hydrogels continue to be important materials for medical applications; therefore, a part of this review is devoted to some of their important classes. Hydrogels are extensively used for various biomedical applications—tissue engineering, molecular imprinting, wound dressings materials, immunoisolation, drug delivery, etc. Thus, this review aims to throw light on the numerous applications that hydrogels have in the biomedical arena.