Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.414 5-Year IF: 3.324 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v28.i6.10
pages 489-552

Recent Trends in Microbially and/or Enzymatically Driven Colon-Specific Drug Delivery Systems

Mayur M. Patel
Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India
Avani Amin
Department of Pharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad - 382 481, Gujarat, India

ABSTRACT

Colon-specific drug delivery systems have recently gained enormous importance for the delivery of a variety of therapeutic compounds. To deliver a drug molecule intact to the colon, the delivery system must pass through the upper part of the gastrointestinal tract without being degraded. Researchers have attempted various approaches in the formulation of colon-specific drug delivery systems. Among them, the most promising are the microbially and/or enzymatically driven drug delivery systems, consisting of biodegradable polymers (polysaccharides) and prodrugs. The major advantage of the microbially and/or enzymatically driven colon-specific drug delivery systems is that they can sense the arrival of the formulation in the colon and release the drug upon activation. This review familiarizes readers with the recent advancements in microbially and/or enzymatically driven colon-specific drug delivery systems, along with their in vitro and in vivo evaluation.


Articles with similar content:

Current Applications of Polysaccharides in Colon Targeting
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.13, 1996, issue 3-4
Helle Brondsted, Lars Hovgaard
Polymer-Drug Conjugates for Anticancer Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 3
Saurabh Wadhwa , Russell J. Mumper
Pharmacoscintigraphy: A Blazing Trail for the Evaluation of New Drugs and Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 4
Prateek Dani, Sanyog Jain, Rakesh Kumar Sharma
Structuring Polymers for Delivery of DNA-Based Therapeutics: Updated Insights
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.29, 2012, issue 6
Suresh P. Vyas, Shailja Tiwari, Madhu Gupta
Immunocytokines for Cancer Therapy
Forum on Immunopathological Diseases and Therapeutics, Vol.5, 2014, issue 1-2
Dario Neri, Philipp Probst