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Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.414 5-Year IF: 3.324 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i6.20
38 pages

Enhancement of Transdermal Drug Delivery: Chemical and Physical Approaches

Charles S. Asbill
McWharter School of Pharmacy, 800 Lakeshore Dr., Birmingham AL 35229
Ayman F. El-Kattan
University of South Carolina, Basic Pharmaceutical Sciences, 700 Sumter St., Columbia, SC 29208
Bozena Michniak
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Lab for Drug Delivery, Newark, New Jersey; University of South Carolina, Basic Pharmaceutical Sciences, 700 Sumter St., Columbia, SC 29208, USA

ABSTRACT

Transdermal drug delivery has been intensively studied over the last two decades because of the many advantages offered by this route of administration. However, the number of drugs used in transdermal drug delivery systems has been somewhat limited, in part resulting from the formidable barrier to drug permeation presented by the upper layer of the skin, the stratum corneum. In order to overcome this, different strategies have been implemented to render the skin more permeable to drugs. These strategies include both chemical and physical approaches. In this review, we outline the enhancing activities and mechanisms of action of some of the more extensively studied chemical penetration enhancers (oxazolidinones, propylene glycol, and epidermal enzymes). In addition, we discuss novel physical strategies, such as the use of microneedles or electroporation.