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Critical Reviews™ in Therapeutic Drug Carrier Systems

Impact factor: 5.367

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v19.i6.10
53 pages

The Colon as a Possible Target for Orally Administered Peptide and Protein Drugs

Susan Moody Haupt
The Hebrew University of Jerusalem, Faculty of Medicine, School of Pharmacy, P.O. Box 12065, Jerusalem, 91120, Israel
Abraham Rubinstein
Chairman, Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine The Adolph Weinberger Building The Hebrew University, P.O. Box 12065 Jerusalem 91120, Israel

ABSTRACT

Oral administration offers a potential portal to the superficial layers of the gas-trointestinal (GI) tract (local delivery) and to the blood and lymphatics (systemic delivery). The harsh hydrolytic environment of the GI tract and the epithelial barriers to absorption, however, pose major challenges to the success of this mode of drug delivery for peptide and protein drugs. One approach to minimizing enzymatic degradation in the GI tract is to target drugs to the apparently less proteolytically active colon. In this review, the evidence supporting the colon as an attractive site for peptide and protein drug delivery will be discussed. The discussion will be confined to specific examples of delivery systems bearing both peptides and proteins that have been tested in the colonic context.