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Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Formulation and Physiological Factors Influencing CNS Delivery upon Intranasal Administration

Volume 23, Issue 4, 2006, pp. 319-347
DOI: 10.1615/CritRevTherDrugCarrierSyst.v23.i4.20
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ABSTRACT

The treatment of central nervous system (CNS) disorders is particularly challenging because of a variety of formidable barriers to effective and persistent delivery of therapeutic compounds. This review discusses the potential of intranasal drug administration as a means to bypass a major barrier, the blood-brain barrier, and allow for direct delivery of drugs into the CNS. The article emphasizes physicochemical properties of intranasal drug formulations as well as relevant anatomical and physiological factors in intranasal delivery of drugs for CNS therapy. Published examples of intranasal administration of small molecular weight drugs, peptides and proteins, and novel formulations for delivering a broad spectrum of molecules are discussed. Finally, the article provides several strategies for effectively enhancing nose-to-brain transport of drug molecules through rational formulation design and optimization.

CITED BY
  1. Tandel Hemal, Florence Kiruba, Misra Ambikanandan, Protein and Peptide Delivery through Respiratory Pathway, in Challenges in Delivery of Therapeutic Genomics and Proteomics, 2011. Crossref

  2. Agrawal Himanshu, Thacker Nipa, Misra Ambikanandan, Parenteral Delivery of Peptides and Proteins, in Challenges in Delivery of Therapeutic Genomics and Proteomics, 2011. Crossref

  3. Cooper Philip R., Ciambrone Gary J., Kliwinski Connie M., Maze Eva, Johnson Lowell, Li Qianqiu, Feng Yiqing, Hornby Pamela J., Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn, Brain Research, 1534, 2013. Crossref

  4. Grondin Yohann, Cotanche Douglas A., Manneberg Otto, Molina Ramon, Treviño-Villarreal J. Humberto, Sepulveda Rosalinda, Clifford Royce, Bortoni Magda E., Forsberg Scott, LaBrecque Brian, Altshul Larisa, Brain Joseph D., Jackson Ronald L., Rogers Rick A., Pulmonary delivery of d-methionine is associated with an increase in ALCAR and glutathione in cochlear fluids, Hearing Research, 298, 2013. Crossref

  5. Dhuria Shyeilla V., Hanson Leah R., Frey William H., Intranasal delivery to the central nervous system: Mechanisms and experimental considerations, Journal of Pharmaceutical Sciences, 99, 4, 2010. Crossref

  6. Moeller Eva Horn, Jorgensen Lene, Alternative routes of administration for systemic delivery of protein pharmaceuticals, Drug Discovery Today: Technologies, 5, 2-3, 2008. Crossref

  7. Brasnjevic Ivona, Steinbusch Harry W.M., Schmitz Christoph, Martinez-Martinez Pilar, Delivery of peptide and protein drugs over the blood–brain barrier, Progress in Neurobiology, 87, 4, 2009. Crossref

  8. SHARMA HARI SHANKER, ALI SYED F., DONG W., TIAN Z. RYAN, PATNAIK R., PATNAIK S., SHARMA ARUNA, BOMAN ARNE, LEK PER, SEIFERT ELISABETH, LUNDSTEDT TORBJÖRN, Drug Delivery to the Spinal Cord Tagged with Nanowire Enhances Neuroprotective Efficacy and Functional Recovery following Trauma to the Rat Spinal Cord, Annals of the New York Academy of Sciences, 1122, 1, 2007. Crossref

  9. Teoh Eng Soon, Galeola to Gymadenia, in Medicinal Orchids of Asia, 2016. Crossref

  10. Barchet Thomas M, Amiji Mansoor M, Challenges and opportunities in CNS delivery of therapeutics for neurodegenerative diseases, Expert Opinion on Drug Delivery, 6, 3, 2009. Crossref

  11. Mandal Surjyanarayan, Mandal Snigdha Das, Chuttani Krishna, Sawant Krutika K, Subudhi Bharat Bhushan, Design and evaluation of mucoadhesive microemulsion for neuroprotective effect of ibuprofen following intranasal route in the MPTP mice model, Drug Development and Industrial Pharmacy, 42, 8, 2016. Crossref

  12. Kaminsky Bonnie M., Bostwick Jolene R., Guthrie Sally K., Alternate Routes of Administration of Antidepressant and Antipsychotic Medications, Annals of Pharmacotherapy, 49, 7, 2015. Crossref

  13. Kadakia Ekta, Bottino Dean, Amiji Mansoor, Mathematical Modeling and Simulation to Investigate the CNS Transport Characteristics of Nanoemulsion-Based Drug Delivery Following Intranasal Administration, Pharmaceutical Research, 36, 5, 2019. Crossref

  14. Sharma Hari Shanker, Ali Syed F., Tian Z. Ryan, Patnaik R., Patnaik S., Sharma Aruna, Boman Arne, Lek Per, Seifert Elisabeth, Lundstedt Torbjörn, Nanowired-Drug Delivery Enhances Neuroprotective Efficacy of Compounds and Reduces Spinal Cord Edema Formation and Improves Functional Outcome Following Spinal Cord Injury in the Rat, in Brain Edema XIV, 106, 2010. Crossref

  15. Dhuria Shyeilla V., Hanson Leah R., Frey William H., Novel Vasoconstrictor Formulation to Enhance Intranasal Targeting of Neuropeptide Therapeutics to the Central Nervous System, Journal of Pharmacology and Experimental Therapeutics, 328, 1, 2009. Crossref

  16. Sharma Hari Shanker, Nanoneuroscience: emerging concepts on nanoneurotoxicity and nanoneuroprotection, Nanomedicine, 2, 6, 2007. Crossref

  17. Agu Remigius U, Challenges in nasal drug absorption: how far have we come?, Therapeutic Delivery, 7, 7, 2016. Crossref

  18. Yadav Sunita, Gattacceca Florence, Panicucci Riccardo, Amiji Mansoor M., Comparative Biodistribution and Pharmacokinetic Analysis of Cyclosporine-A in the Brain upon Intranasal or Intravenous Administration in an Oil-in-Water Nanoemulsion Formulation, Molecular Pharmaceutics, 12, 5, 2015. Crossref

  19. Crowe Tyler P., Hsu Walter H., Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System, Pharmaceutics, 14, 3, 2022. Crossref

  20. Appolinario Camila M, Jackson Alan C, Antiviral Therapy for Human Rabies, Antiviral Therapy, 20, 1, 2015. Crossref

  21. Serralheiro Ana, Alves Gilberto, Fortuna Ana, Falcão Amílcar, Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting, European Journal of Pharmaceutical Sciences, 60, 2014. Crossref

  22. Dhuyvetter Deborah, Tekle Fetene, Nazarov Maxim, Vreeken Rob J., Borghys Herman, Rombouts Frederik, Lenaerts Ilse, Bottelbergs Astrid, Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats, Drug Delivery, 27, 1, 2020. Crossref

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