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Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Advances in Buccal Drug Delivery

Volume 22, Issue 3, 2005, pp. 295-330
DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i3.20
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ABSTRACT

The buccal route offers an attractive alternative for systemic drug delivery of drugs because of better patient compliance, ease of dosage form removal in emergencies, robustness, and good accessibility. Use of buccal mucosa for drug absorption was first attempted by Sobrero in 1847, and since then much research was done to deliver drugs through this route. Today, research is more focused on the development of suitable delivery devices, permeation enhancement, and buccal delivery of drugs that undergo a first-pass effect, such as cardiovascular drugs, analgesics, and peptides. In addition, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity. In this review, the anatomy and physiology of buccal mucosa, followed by discussion of recent literature on the buccal permeation enhancement, and pathways of enhancement for various molecules are detailed. In addition, bioadhesion theories from historic perspective and current status are discussed. The various dosage forms on the market and in different stages of development are also reviewed.

CITED BY
  1. Di Colo Giacomo, Zambito Ylenia, Zaino Chiara, Polymeric Enhancers of Mucosal Epithelia Permeability: Synthesis, Transepithelial Penetration-Enhancing Properties, Mechanism of Action, Safety Issues, Journal of Pharmaceutical Sciences, 97, 5, 2008. Crossref

  2. Morley Paul, Delivery of parathyroid hormone for the treatment of osteoporosis, Expert Opinion on Drug Delivery, 2, 6, 2005. Crossref

  3. Surapaneni Madhu S., Das Sudip K., Das Nandita G., Effect of Excipient and Processing Variables on Adhesive Properties and Release Profile of Pentoxifylline From Mucoadhesive Tablets, Drug Development and Industrial Pharmacy, 32, 3, 2006. Crossref

  4. Kulkarni Upendra Dilip, Mahalingam Ravichandran, Li Xiaoling, Pather Indiran, Jasti Bhaskara, Effect of Experimental Temperature on the Permeation of Model Diffusants Across Porcine Buccal Mucosa, AAPS PharmSciTech, 12, 2, 2011. Crossref

  5. Losso Jack, Development and Delivery of Anti-Angiogenic Functional Food Products, in Anti-Angiogenic Functional and Medicinal Foods, 20072347, 2007. Crossref

  6. Smistad Gro, Nguyen Nguyen Binh, Hegna Ida Kristin, Sande Sverre Arne, Influence of liposomal formulation variables on the interaction withCandida albicansin biofilm; a multivariate approach, Journal of Liposome Research, 21, 1, 2011. Crossref

  7. Smistad Gro, Jacobsen Jette, Sande Sverre A., Multivariate toxicity screening of liposomal formulations on a human buccal cell line, International Journal of Pharmaceutics, 330, 1-2, 2007. Crossref

  8. Dixit R.P., Puthli S.P., Oral strip technology: Overview and future potential, Journal of Controlled Release, 139, 2, 2009. Crossref

  9. Kulkarni Upendra, Mahalingam Ravichandran, Pather Indiran, Li Xiaoling, Jasti Bhaskara, Porcine buccal mucosa as in vitro model: Effect of biological and experimental variables, Journal of Pharmaceutical Sciences, 99, 3, 2010. Crossref

  10. Wen Hong, Park Kinam, Introduction and Overview of Oral Controlled Release Formulation Design, in Oral Controlled Release Formulation Design and Drug Delivery, 2010. Crossref

  11. Scholz Oliver A., Wolff Andy, Schumacher Axel, Giannola Libero I., Campisi Giuseppina, Ciach Tomasz, Velten Thomas, Drug delivery from the oral cavity: focus on a novel mechatronic delivery device, Drug Discovery Today, 13, 5-6, 2008. Crossref

  12. Madhav N.V. Satheesh, Shakya Ashok K., Shakya Pragati, Singh Kuldeep, Orotransmucosal drug delivery systems: A review, Journal of Controlled Release, 140, 1, 2009. Crossref

  13. Cavallari Cristina, Fini Adamo, Ospitali Francesca, Mucoadhesive multiparticulate patch for the intrabuccal controlled delivery of lidocaine, European Journal of Pharmaceutics and Biopharmaceutics, 83, 3, 2013. Crossref

  14. Kianfar Farnoosh, Chowdhry Babur Z., Antonijevic Milan D., Boateng Joshua S., Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs, Drug Development and Industrial Pharmacy, 38, 10, 2012. Crossref

  15. Perioli Luana, Pagano Cinzia, Preformulation studies of mucoadhesive tablets for carbamazepine sublingual administration, Colloids and Surfaces B: Biointerfaces, 102, 2013. Crossref

  16. Satheesh Madhav Nookala Venkala, Semwal Ravindra, Semwal Deepak Kumar, Semwal Ruchi B, Recent trends in oral transmucosal drug delivery systems: an emphasis on the soft palatal route, Expert Opinion on Drug Delivery, 9, 6, 2012. Crossref

  17. Sander Camilla, Madsen Katrine Dragsbæk, Hyrup Birgitte, Nielsen Hanne Mørck, Rantanen Jukka, Jacobsen Jette, Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration, European Journal of Pharmaceutics and Biopharmaceutics, 85, 3, 2013. Crossref

  18. Holm René, Meng-Lund Emil, Andersen Morten B., Jespersen Mads L., Karlsson Jens-Jacob, Garmer Mats, Jørgensen Erling B., Jacobsen Jette, In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs, European Journal of Pharmaceutical Sciences, 49, 2, 2013. Crossref

  19. Muppalaneni Srinath, Mastropietro David, Omidian Hossein, Mucoadhesive Drug Delivery Systems, in Engineering Polymer Systems for Improved Drug Delivery, 2014. Crossref

  20. Khan Sajjad, Boateng Joshua S., Mitchell John, Trivedi Vivek, Formulation, Characterisation and Stabilisation of Buccal Films for Paediatric Drug Delivery of Omeprazole, AAPS PharmSciTech, 16, 4, 2015. Crossref

  21. Zaman Muhammad, Sajid Nayab, Rehman Atta Ur, Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review, Advances in Polymer Technology, 35, 3, 2016. Crossref

  22. Abruzzo Angela, Cerchiara Teresa, Bigucci Federica, Gallucci Maria Caterina, Luppi Barbara, Mucoadhesive Buccal Tablets Based on Chitosan/Gelatin Microparticles for Delivery of Propranolol Hydrochloride, Journal of Pharmaceutical Sciences, 104, 12, 2015. Crossref

  23. Barua Sonia, Kim Hyeongmin, Jo Kanghee, Seo Chang Won, Park Tae Jun, Lee Kyung Bin, Yun Gyiae, Oh Kyungsoo, Lee Jaehwi, Drug delivery techniques for buccal route: formulation strategies and recent advances in dosage form design, Journal of Pharmaceutical Investigation, 46, 7, 2016. Crossref

  24. Sohi Harmik, Ahuja Alka, Ahmad Farhan Jalees, Khar Roop Krishen, Critical evaluation of permeation enhancers for oral mucosal drug delivery, Drug Development and Industrial Pharmacy, 36, 3, 2010. Crossref

  25. Parodi Brunella, Russo Eleonora, Baldassari Sara, Zuccari Guendalina, Pastorino Sara, Yan Mengying, Neduri Karthik, Caviglioli Gabriele, Development and characterization of a mucoadhesive sublingual formulation for pain control: extemporaneous oxycodone films in personalized therapy, Drug Development and Industrial Pharmacy, 43, 6, 2017. Crossref

  26. Campos João C., Cunha João D., Ferreira Domingos C., Reis Salette, Costa Paulo J., Challenges in the local delivery of peptides and proteins for oral mucositis management, European Journal of Pharmaceutics and Biopharmaceutics, 128, 2018. Crossref

  27. Davydova V. N., Volod’ko A. V., Mishchenko N. P., Yermak I. M., Chitosan-Based Mucoadhesive Systems for the Inclusion of the Echinochrome Active Substance, Applied Biochemistry and Microbiology, 54, 5, 2018. Crossref

  28. Svider Peter F., Warner Blake M., Schwartz Scott J., Garshott Danielle M., Weinstein James D., Fribley Andrew M., Mucosal Therapy for Potentially Malignant Diseases and OSCC, in Targeting Oral Cancer, 2016. Crossref

  29. Garshott Danielle M., Bechler Shelby A., Burchhardt Daniela M., O’Brien Priyanka Shah, Yoo George H., Chiego Daniel J., Rehman Aasia O., Callaghan Michael U., Fribley Andrew M., The Unfolded Protein Response as a Therapeutic Target for Head and Neck Squamous Cell Carcinoma, in Targeting Oral Cancer, 2016. Crossref

  30. Parvathaneni Vineela, Kulkarni Nishant S., Gupta Vivek, Current Status and Perspectives in Mucosal Drug Delivery of Nanotherapeutic Systems, in Mucosal Delivery of Drugs and Biologics in Nanoparticles, 41, 2020. Crossref

  31. Sharma Manu, Rathore Aishwarya, Sharma Sheelu, Sadhu Veera, Reddy Kakarla Raghava, Kulkarni Raghavendra V., Recent progress in mucoadhesive polymers for buccal drug delivery applications, in Nanomaterials in Diagnostic Tools and Devices, 2020. Crossref

  32. Kharenko E. A., Larionova N. I., Demina N. B., Mucoadhesive Drug Delivery Systems: Quantitative Assessment of Interaction Between Synthetic and Natural Polymer Films and Mucosa, Pharmaceutical Chemistry Journal, 42, 7, 2008. Crossref

  33. Kharenko E. A., Larionova N. I., Demina N. B., Mucoadhesive drug delivery systems (Review), Pharmaceutical Chemistry Journal, 43, 4, 2009. Crossref

  34. Jacob Shery, Nair Anroop B., Boddu Sai H. S., Gorain Bapi, Sreeharsha Nagaraja, Shah Jigar, An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems, Pharmaceutics, 13, 8, 2021. Crossref

  35. Wanasathop Apipa, Patel Priya B, Choi Hyojin A., Li S. Kevin, Permeability of Buccal Mucosa, Pharmaceutics, 13, 11, 2021. Crossref

  36. Yermak Irina M., Davydova Viktoriya N., Volod’ko Aleksandra V., Mucoadhesive Marine Polysaccharides, Marine Drugs, 20, 8, 2022. Crossref

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