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Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.414 5-Year IF: 3.324 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2014008126
pages 219-272

Novel Strategies for Effective Transdermal Drug Delivery: A Review

Ankita Jain
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Priyanka Jain
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Jaya Kurmi
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Darshana Jain
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Roshni Jain
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Silky Chandel
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Anamika Sahu
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Nishi Mody
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Satish Upadhaya
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India
Aviral Jain
Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar (M. P.) 470003, India

ABSTRACT

Skin is the largest and easily accessible organ of the body and therefore can be extensively used as a prominent route of delivery for local and systemic effects. Though it presents a multifunctional barrier between body and surrounding particles, there are chances to deliver therapeutic nanocarrier, particularly in diseased skin. Both for dermal and transdermal drug delivery, the horny layer, i.e., the uppermost layer of the skin serve as the most resistant layer to be crossed and for this purpose, different perforation techniques are used that relatively widen the skin opening and allow the passage of drug (≤ 10 mg) and micromolecules, but this amateur disruption of the skin can be avoided in order to preserve this barrier against cutaneous microbiota by using deformable nanocarriers. In this review, we discuss the nanosized aggregates and microneedle technology for the advanced delivery of vaccines, protein, peptides, nucleic acid, and hormone across the skin.


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