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Critical Reviews™ in Therapeutic Drug Carrier Systems

Impact factor: 5.367

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2014008193
pages 187-217

Recent Advances in Polymeric Electrospun Nanofibers for Drug Delivery

Rahul Sharma
Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga (Punjab), India
Harmanpreet Singh
Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga (Punjab), India
Munish Joshi
Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga (Punjab), India
Abhinandan Sharma
Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga (Punjab), India
Tarun Garg
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India
Amit Kumar Goyal
Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India; Punjab Technical University, Kapurthala, Punjab, India
Goutam Rath
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India; Punjab Technical University, Kapurthala, Punjab, India

ABSTRACT

Electrospinning is a simple unit operation process by which polymeric nanofibers with diameters ranging from a few nanometers to hundreds of micrometers can be fabricated using an electrostatically operated jet of polymer solution or polymer melt. Nanofibers because of their interesting features, such as surface-to-volume ratio, high surface area, microporosity, and nonwoven structure, provide numerous opportunities to design novel carrier systems for large commodities of therapeutics. Physicochemical properties of nanofibers depend on several process and formulation parameters, such as applied voltage, flow rate, polymer selection, and concentration of polymer used. The applications of nanofibers in drug delivery are nearly unbounded. This review summarizes the most recent work done on the various physicochemical parameters of electrospinning and polymers used in making wide varieties of nanofibers along with their role in developing more effective, novel drug delivery systems.