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ISSN Print: 0743-4863
ISSN Online: 2162-660X
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Factors Affecting Drug and Gene Delivery: Effects of Interaction with Blood Components
ABSTRACT
Targeted drug delivery systems have been used extensively to improve the pharmacological and therapeutic activities of a wide variety of drugs and genes. In this article, we summarize the factors determining the tissue disposition of delivery systems: the physicochemical and biological characteristics of the delivery system and the anatomic and physiological characteristics of the tissues. There are several modes of drug and gene targeting, ranging from passive to active targeting, and each of these can be achieved by optimizing the design of the delivery system to suit a specific aim. After entering the systemic circulation, either by an intravascular injection or through absorption from an administration site, however, a delivery system encounters a variety of blood components, including blood cells and a range of serum proteins. These components are by no means inert as far as interaction with the delivery system is concerned, and they can sometimes markedly effect its tissue disposition. The interaction with blood components is known to occur with particulate delivery systems, such as liposomes, or with cationic charge-mediated delivery systems for genes. In addition to these rather nonspecific ones, interactions via the targeting ligand of the delivery system can occur. We recently found that mannosylated carriers interact with serum mannan binding protein, greatly altering their tissue disposition in a number of ways that depend on the properties of the carriers involved.
-
Sheng Yan, Yuan Yuan, Liu Changsheng, Tao Xinyi, Shan Xiaoqian, Xu Feng, In vitro macrophage uptake and in vivo biodistribution of PLA–PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content, Journal of Materials Science: Materials in Medicine, 20, 9, 2009. Crossref
-
Wu Sherry Y., Putral Lisa N., Liang Mingtao, Chang Hsin-I., Davies Nigel M., McMillan Nigel A. J., Development of a Novel Method for Formulating Stable siRNA-Loaded Lipid Particles for In vivo Use, Pharmaceutical Research, 26, 3, 2009. Crossref
-
Xie Guangping, Sun Jiao, Zhong Gaoren, Shi Liyi, Zhang Dawei, Biodistribution and toxicity of intravenously administered silica nanoparticles in mice, Archives of Toxicology, 84, 3, 2010. Crossref
-
NISHIKAWA Makiya, Optimization of <i>In Vivo</i> Gene Transfer through Regulating Biological Response to Vectors, YAKUGAKU ZASSHI, 126, 11, 2006. Crossref
-
Li Weijun, Szoka Francis C., Lipid-based Nanoparticles for Nucleic Acid Delivery, Pharmaceutical Research, 24, 3, 2007. Crossref
-
Prokop Ales, Davidson Jeffrey M., Nanovehicular Intracellular Delivery Systems, Journal of Pharmaceutical Sciences, 97, 9, 2008. Crossref
-
Nishikawa Makiya, Hashida Mitsuru, Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes, Expert Opinion on Drug Delivery, 3, 3, 2006. Crossref
-
Nishikawa Makiya, Takakura Yoshinobu, Hashida Mitsuru, Pharmacokinetic considerations regarding non-viral cancer gene therapy, Cancer Science, 99, 5, 2008. Crossref
-
Fattal Elias, Barratt Gillian, Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA, British Journal of Pharmacology, 157, 2, 2009. Crossref
-
Reed M.L., Lye W.-K., Microsystems for Drug and Gene Delivery, Proceedings of the IEEE, 92, 1, 2004. Crossref
-
Nishikawa Makiya, Development of Cell-Specific Targeting Systems for Drugs and Genes, Biological and Pharmaceutical Bulletin, 28, 2, 2005. Crossref
-
Pavan Giovanni Maria, Posocco Paola, Tagliabue Aaron, Maly Marek, Malek Anastasia, Danani Andrea, Ragg Enzio, Catapano Carlo V., Pricl Sabrina, PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights, Chemistry - A European Journal, 16, 26, 2010. Crossref
-
Bagalkot Vaishali, Kyung YU Mi, Jon Sangyong, Nanoparticles for Combined Cancer Imaging and Therapy, in Nanoplatform-Based Molecular Imaging, 2011. Crossref
-
Yao Jing, Zhou Jian Ping, Ping Qi Neng, Lu Yun, Chen Liang, Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice, International Journal of Pharmaceutics, 352, 1-2, 2008. Crossref
-
Benoit D.S.W., Gray W., Murthy N., Li H., Duvall C.L., pH-Responsive Polymers for the Intracellular Delivery of Biomolecular Drugs, in Comprehensive Biomaterials, 2011. Crossref
-
Fattal Elias, Bochot Amélie, State of the art and perspectives for the delivery of antisense oligonucleotides and siRNA by polymeric nanocarriers, International Journal of Pharmaceutics, 364, 2, 2008. Crossref
-
Xie Guangping, Wang Chen, Sun Jiao, Zhong Gaoren, Tissue distribution and excretion of intravenously administered titanium dioxide nanoparticles, Toxicology Letters, 205, 1, 2011. Crossref
-
Bahmani Baharak, Gupta Sharad, Upadhyayula Srigokul, Vullev Valentine I., Anvari Bahman, Effect of polyethylene glycol coatings on uptake of indocyanine green loaded nanocapsules by human spleen macrophages in vitro, Journal of Biomedical Optics, 16, 5, 2011. Crossref
-
Wang Xin Yu, Ishida Tatsuhiro, Ichihara Masako, Kiwada Hiroshi, Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats, Journal of Controlled Release, 104, 1, 2005. Crossref
-
Schladt Thomas D., Schneider Kerstin, Schild Hansjörg, Tremel Wolfgang, Synthesis and bio-functionalization of magnetic nanoparticles for medical diagnosis and treatment, Dalton Transactions, 40, 24, 2011. Crossref
-
Chaturvedi Kiran, Ganguly Kuntal, Kulkarni Anandrao R, Kulkarni Venkatarao H, Nadagouda Mallikarjuna N, Rudzinski Walter E, Aminabhavi Tejraj M, Cyclodextrin-based siRNA delivery nanocarriers: a state-of-the-art review, Expert Opinion on Drug Delivery, 8, 11, 2011. Crossref
-
Petrak Karel, Essential properties of drug-targeting delivery systems, Drug Discovery Today, 10, 23-24, 2005. Crossref
-
Avti Pramod, Patel Sunny, Nanobiomaterials, in Nanobiomaterials Handbook, 2011. Crossref
-
Opanasopit Praneet, Yokoyama Masayuki, Watanabe Masato, Kawano Kumi, Maitani Yoshie, Okano Teruo, Influence of serum and albumins from different species on stability of camptothecin-loaded micelles, Journal of Controlled Release, 104, 2, 2005. Crossref
-
Gunaseelan Simi, Gunaseelan Krishnan, Deshmukh Manjeet, Zhang Xiaoping, Sinko Patrick J., Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs, Advanced Drug Delivery Reviews, 62, 4-5, 2010. Crossref
-
Hawat Ghayda, Hélie Pierre, Baroudi Ghayath, Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction, Journal of Molecular and Cellular Cardiology, 53, 4, 2012. Crossref
-
Shalviri Alireza, Cai Ping, Rauth Andrew M., Henderson Jeffery T., Wu Xiao Yu, Evaluation of new bi-functional terpolymeric nanoparticles for simultaneous in vivo optical imaging and chemotherapy of breast cancer, Drug Delivery and Translational Research, 2, 6, 2012. Crossref
-
Yamashita Fumiyoshi, Hashida Mitsuru, Pharmacokinetic considerations for targeted drug delivery, Advanced Drug Delivery Reviews, 65, 1, 2013. Crossref
-
Landsiedel Robert, Fabian Eric, Ma-Hock Lan, Wohlleben Wendel, Wiench Karin, Oesch Franz, van Ravenzwaay Ben, Toxico-/biokinetics of nanomaterials, Archives of Toxicology, 86, 7, 2012. Crossref
-
Süleymanoğlu Erhan, Preparation and phase behaviour of surface-active pharmaceuticals: self-assembly of DNA and surfactants with membranes. Differential adiabatic scanning microcalorimetric study, Il Farmaco, 60, 8, 2005. Crossref
-
Ernsting Mark J., Murakami Mami, Roy Aniruddha, Li Shyh-Dar, Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles, Journal of Controlled Release, 172, 3, 2013. Crossref
-
Mishra Nidhi, Yadav Narayan Prasad, Rai Vineet Kumar, Sinha Priyam, Yadav Kuldeep Singh, Jain Sanyog, Arora Sumit, Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance, BioMed Research International, 2013, 2013. Crossref
-
Biswas Swati, Vaze Onkar S., Movassaghian Sara, Torchilin Vladimir P., Polymeric Micelles for the Delivery of Poorly Soluble Drugs, in Drug Delivery Strategies for Poorly Water-Soluble Drugs, 2013. Crossref
-
Rosenkranz A. A., Ulasov A. V., Slastnikova T. A., Khramtsov Y. V., Sobolev A. S., Use of intracellular transport processes for targeted drug delivery into a specified cellular compartment, Biochemistry (Moscow), 79, 9, 2014. Crossref
-
Yang Liang, Lee Young-Chul, Kim Moon Il, Park Hyun Gyu, Huh Yun Suk, Shao Yating, Han Hyo-Kyung, Biodistribution and clearance of aminoclay nanoparticles: implication for in vivo applicability as a tailor-made drug delivery carrier, J. Mater. Chem. B, 2, 43, 2014. Crossref
-
Yousefi Afrouz, Bourajjaj Meriem, Babae Negar, Noort Paula I. van, Schaapveld Roel Q.J., Beijnum Judy R. van, Griffioen Arjan W., Storm Gert, Schiffelers Raymond M., Mastrobattista Enrico, Anginex lipoplexes for delivery of anti-angiogenic siRNA, International Journal of Pharmaceutics, 472, 1-2, 2014. Crossref
-
Liu Ting, Choi Hoon, Zhou Rong, Chen I-Wei, RES blockade: A strategy for boosting efficiency of nanoparticle drug, Nano Today, 10, 1, 2015. Crossref
-
Florence Alexander T., Issues in Oral Nanoparticle Drug Carrier Uptake and Targeting, Journal of Drug Targeting, 12, 2, 2004. Crossref
-
Huang Leaf, Sullenger Bruce, Juliano Rudy, The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides, Journal of Drug Targeting, 18, 8, 2010. Crossref
-
Fujihara Junko, Tongu Miki, Hashimoto Hideki, Yamada Takaya, Kimura-Kataoka Kaori, Yasuda Toshihiro, Fujita Yasuhisa, Takeshita Haruo, Distribution and toxicity evaluation of ZnO dispersion nanoparticles in single intravenously exposed mice, The Journal of Medical Investigation, 62, 1.2, 2015. Crossref
-
Zhao Jingjing, Zhang Bo, Shen Shun, Chen Jun, Zhang Qizhi, Jiang Xinguo, Pang Zhiqing, CREKA peptide-conjugated dendrimer nanoparticles for glioblastoma multiforme delivery, Journal of Colloid and Interface Science, 450, 2015. Crossref
-
Jiao Sun , Guangping Xie , Tissue distribution of intravenously administrated hydroxyapatite nanoparticles labeled with <sup>125</sup>I, 2010 3rd International Nanoelectronics Conference (INEC), 2010. Crossref
-
Liu Jinfeng, Teng Li, Liu Chunhui, Hu Likuan, Wang Yonggang, Liu Hong, Wang Fengshan, Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by chemical modification with polysaccharide and attenuation effects on radiation-induced inflammatory cytokine expression in vitro, Journal of Drug Targeting, 17, 3, 2009. Crossref
-
Bondì Maria Luisa, Craparo Emanuela Fabiola, Solid lipid nanoparticles for applications in gene therapy: a review of the state of the art, Expert Opinion on Drug Delivery, 7, 1, 2010. Crossref
-
Agotegaray Mariela A., Lassalle Verónica L., Biomedical Features, in Silica-coated Magnetic Nanoparticles, 2017. Crossref
-
Guan Jibin, Sun Jin, Sun Feilong, Lou Bo, Zhang Dong, Mashayekhi Vida, Sadeghi Negar, Storm Gert, Mastrobattista Enrico, He Zhonggui, Hypoxia-induced tumor cell resistance is overcome by synergistic GAPDH-siRNA and chemotherapy co-delivered by long-circulating and cationic-interior liposomes, Nanoscale, 9, 26, 2017. Crossref
-
Benoit D.S.W., Gray W., Murthy N., Li H., Duvall C.L., 4.26 pH-Responsive Polymers for the Intracellular Delivery of Biomolecular Drugs, in Comprehensive Biomaterials II, 2017. Crossref
-
Adumeau Laurent, Genevois Coralie, Roudier Lydia, Schatz Christophe, Couillaud Franck, Mornet Stéphane, Impact of surface grafting density of PEG macromolecules on dually fluorescent silica nanoparticles used for the in vivo imaging of subcutaneous tumors, Biochimica et Biophysica Acta (BBA) - General Subjects, 1861, 6, 2017. Crossref
-
Dan Nily, Core–shell drug carriers: liposomes, polymersomes, and niosomes, in Nanostructures for Drug Delivery, 2017. Crossref
-
Sergeeva Yulia N., Jung Laura, Weill Claire, Erbacher Patrick, Tropel Philippe, Felix Olivier, Viville Stéphane, Decher Gero, Control of the transfection efficiency of human dermal fibroblasts by adjusting the characteristics of jetPEI®/plasmid complexes/polyplexes through the cation/anion ratio, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 550, 2018. Crossref
-
Waegeneers Nadia, Brasseur Anne, Van Doren Elke, Van der Heyden Sara, Serreyn Pieter-Jan, Pussemier Luc, Mast Jan, Schneider Yves-Jacques, Ruttens Ann, Roels Stefan, Short-term biodistribution and clearance of intravenously administered silica nanoparticles, Toxicology Reports, 5, 2018. Crossref
-
Khademi Farzad, Taheri Ramezan Ali, Momtazi-Borojeni Amir Abbas, Farnoosh Gholamreza, Johnston Thomas P., Sahebkar Amirhossein, Potential of Cationic Liposomes as Adjuvants/Delivery Systems for Tuberculosis Subunit Vaccines, in Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175, 175, 2018. Crossref
-
Mokhtarieh Amir Abbas, Lee Jieun, Kim Semi, Lee Myung Kyu, Preparation of siRNA encapsulated nanoliposomes suitable for siRNA delivery by simply discontinuous mixing, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860, 6, 2018. Crossref
-
Kumar Rajiv, Roy Indrajit, Ohulchanskky Tymish Y., Vathy Lisa A., Bergey Earl J., Sajjad Munawwar, Prasad Paras N, In Vivo Biodistribution and Clearance Studies Using Multimodal Organically Modified Silica Nanoparticles, ACS Nano, 4, 2, 2010. Crossref
-
Dan Nily, Vesicle-based drug carriers, in Design and Development of New Nanocarriers, 2018. Crossref
-
Nishikawa Makiya, Pharmacokinetic Properties of Nanomaterials, in Nanomaterials in Pharmacology, 2016. Crossref
-
Li Shyh-Dar, Huang Leaf, Pharmacokinetics and Biodistribution of Nanoparticles, Molecular Pharmaceutics, 5, 4, 2008. Crossref
-
Sachar Ravish, Topol Eric J., Local Gene and Cell Delivery Devices, in Essentials of Restenosis, 2007. Crossref
-
Nishikawa Makiya, Tan Mengmeng, Liao Wenqing, Kusamori Kosuke, Nanostructured DNA for the delivery of therapeutic agents, Advanced Drug Delivery Reviews, 147, 2019. Crossref
-
Zamay Galina S., Zamay Tatiana N., Lukyanenko Kirill A., Kichkailo Anna S., Aptamers Increase Biocompatibility and Reduce the Toxicity of Magnetic Nanoparticles Used in Biomedicine, Biomedicines, 8, 3, 2020. Crossref
-
Silvero C. M. Jazmín, Rocca Diamela M., de la Villarmois Emilce Artur, Fournier Kelsey, Lanterna Anabel E., Pérez Mariela F., Becerra M. Cecilia, Scaiano Juan C., Selective Photoinduced Antibacterial Activity of Amoxicillin-Coated Gold Nanoparticles: From One-Step Synthesis to in Vivo Cytocompatibility, ACS Omega, 3, 1, 2018. Crossref
-
Kumbhar Smita T., Patil Shitalkumar S., Bhatia Manish S., Thorata Yogesh S., A REVIEW ON BASICS AND APPLICATIONS OF MODIFIED CARBOHYDRATES IN DRUG DELIVERY, INDIAN DRUGS, 58, 02, 2021. Crossref
-
Ram Kumar Pandian Sureshbabu, Rencilin Clayton Fernando, Sundar Krishnan, Emerging nanomaterials for cancer immunotherapy, Exploration of Medicine, 2, 3, 2021. Crossref
-
Sunshine Joel C, Bishop Corey J, Green Jordan J, Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery, Therapeutic Delivery, 2, 4, 2011. Crossref
-
Mortimer Gysell M., Butcher Neville J., Musumeci Anthony W., Deng Zhou J., Martin Darren J., Minchin Rodney F., Cryptic Epitopes of Albumin Determine Mononuclear Phagocyte System Clearance of Nanomaterials, ACS Nano, 8, 4, 2014. Crossref
-
Muñoz-Úbeda Mónica, Semenzato Martina, Franco-Romero Anais, Junquera Elena, Aicart Emilio, Scorrano Luca, López-Montero Iván, Transgene expression in mice of the Opa1 mitochondrial transmembrane protein through bicontinuous cubic lipoplexes containing gemini imidazolium surfactants, Journal of Nanobiotechnology, 19, 1, 2021. Crossref
-
Malfatti Michael A., Palko Heather A., Kuhn Edward A., Turteltaub Kenneth W., Determining the Pharmacokinetics and Long-Term Biodistribution of SiO2 Nanoparticles In Vivo Using Accelerator Mass Spectrometry, Nano Letters, 12, 11, 2012. Crossref
-
Gasperini Antonio A. M., Puentes-Martinez Ximena E., Balbino Tiago Albertini, de Paula Rigoletto Thais, de Sá Cavalcanti Corrêa Gabriela, Cassago Alexandre, Portugal Rodrigo Villares, de La Torre Lucimara Gaziola, Cavalcanti Leide P., Association between Cationic Liposomes and Low Molecular Weight Hyaluronic Acid, Langmuir, 31, 11, 2015. Crossref
-
Mokhtarieh Amir Abbas, Cheong Sinyoung, Kim Semi, Chung Bong Hyun, Lee Myung Kyu, Asymmetric liposome particles with highly efficient encapsulation of siRNA and without nonspecific cell penetration suitable for target-specific delivery, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818, 7, 2012. Crossref
-
González-Rubio Sergio, Salgado Cástor, Manzaneda-González Vanesa, Muñoz-Úbeda Mónica, Ahijado-Guzmán Rubén, Natale Paolo, Almendro-Vedia Víctor G., Junquera Elena, Barcina José Osío, Ferrer Irene, Guerrero-Martínez Andrés, Paz-Ares Luis, López-Montero Iván, Tunable gold nanorod/NAO conjugates for selective drug delivery in mitochondria-targeted cancer therapy, Nanoscale, 14, 22, 2022. Crossref
-
Nainwani Sakshi, Tyagi Anushka, Pathak Yashwant V., Gupta Swati, Macrophage Targeting for Therapy of HIV, in Macrophage Targeted Delivery Systems, 2022. Crossref
-
Ma Shen-Feng, Nishikawa Makiya, Katsumi Hidemasa, Yamashita Fumiyoshi, Hashida Mitsuru, Cationic charge-dependent hepatic delivery of amidated serum albumin, Journal of Controlled Release, 102, 3, 2005. Crossref
-
Ma Shen-Feng, Nishikawa Makiya, Katsumi Hidemasa, Yamashita Fumiyoshi, Hashida Mitsuru, Liver targeting of catalase by cationization for prevention of acute liver failure in mice, Journal of Controlled Release, 110, 2, 2006. Crossref
-
Mukai Hidefumi, Ogawa Koki, Kato Naoya, Kawakami Shigeru, Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics, Drug Metabolism and Pharmacokinetics, 44, 2022. Crossref
-
Islam Farhadul, Zhou Yaoqi, Lam Alfred K., Liposomal siRNA Delivery in Papillary Thyroid Carcinoma Cells, in Papillary Thyroid Carcinoma, 2534, 2022. Crossref
-
Ignjatović Nenad, Vranješ Djurić Sanja, Mitić Žarko, Janković Drina, Uskoković Dragan, Investigating an organ-targeting platform based on hydroxyapatite nanoparticles using a novel in situ method of radioactive 125Iodine labeling, Materials Science and Engineering: C, 43, 2014. Crossref
-
Qu Guowei, Wu Xiaoli, Yin Lifang, Zhang Can, N-octyl-O-sulfate chitosan-modified liposomes for delivery of docetaxel: Preparation, characterization, and pharmacokinetics, Biomedicine & Pharmacotherapy, 66, 1, 2012. Crossref
-
Sivasubramanian Maharajan, Lin Li-Jie, Wang Yu-Chao, Yang Chung-Shi, Lo Leu-Wei, Industrialization’s eye view on theranostic nanomedicine, Frontiers in Chemistry, 10, 2022. Crossref
-
Mihaila Radu, Ruhela Dipali, Galinski Beverly, Card Ananda, Cancilla Mark, Shadel Timothy, Kang Jing, Tep Samnang, Wei Jie, Haas R. Matthew, Caldwell Jeremy, Flanagan W. Michael, Kuklin Nelly, Cherkaev Elena, Ason Brandon, Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2, Molecular Therapy - Nucleic Acids, 16, 2019. Crossref
-
Mishra Ashwini Kumar, Pandey Mukesh, Dewangan Hitesh Kumar, SL Neha, Sahoo Pravat Kumar, A Comprehensive Review on Liver Targeting: Emphasis on Nanotechnology- based Molecular Targets and Receptors Mediated Approaches, Current Drug Targets, 23, 15, 2022. Crossref