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Critical Reviews™ in Therapeutic Drug Carrier Systems

Impact factor: 5.367

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v15.i4.20
40 pages

Bioerodible Polymers for Ocular Drug Delivery

A. A. Deshpande
School of Pharmacy, University of Geneva, 30 quai Ernest-Ansermet, 1211 Geneva 4, Switzerland
J. Heller
Advanced Polymer Systems, Redwood City, CA 94063, USA
R. Gurny
School of Pharmacy, University of Geneva, 30 quai Ernest-Ansermet, 1211 Geneva 4, Switzerland

ABSTRACT

Development of ophthalmic drug-delivery systems has always been challenging. The commonly used route for drug delivery to the anterior segment of the eye has been the conjunctival cul-de-sac. Because of drawbacks associated with this route, new approaches have been investigated for delivery of drugs to the eye by means of polymeric delivery systems. Development of controlled drug-release devices has been a major step forward in this respect. Bioerodible polymers have been at the forefront of such systems. They are very important because they eliminate the need for removing the implant after complete drug release. Bioerodible polymers have been divided into three classes based on their mechanism of hydrolysis: Type I—hydrolysis of crosslinked hydrogels; Type II—solubilization by ionization or hydrolysis of linear polymers; and Type III—biodegradation by backbone cleavage. Polymers from all three classes are discussed in detail in this review.