Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Oncogenesis
SJR: 0.946 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v12.i3-4.50
pages 273-287

Colorectal Cancer: A Multipathway Disease

Jeremy R. Jass
Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec H3A 2B4, Canada

ABSTRACT

The linear sequence of genetic alterations illustrated in the Vogelstein model provides a readily understandable illustration of the fundamental principles underlying colorectal tumorigenesis. However, it is now clear that colorectal cancer is a multi-pathway disease. In this review, the concept that inactivation of the tumor suppressor gene APC serves to initiate virtually all colorectal cancers is shown to be an oversimplification. APC inactivation may have important tumorigenic pathogenic effects beyond the mere initiation of precancerous adenomas. Furthermore, the early evolution of colorectal neoplasia must sometimes occur by mechanisms other than inactivation of APC or related alterations that would drive dysregulated Wnt pathway signaling. Oncogenic mutations implicating both BRAF and KRAS are highlighted as alternative initiating steps that synergize with DNA methylation and occur within the context of serrated polyps. CRC comprises subgroups with particular clinical, pathological, and molecular features.


Articles with similar content:

Ikaros and Tumor Suppression in Acute Lymphoblastic Leukemia
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 1-2
Sinisa Dovat, Kimberly J. Payne
Homeobox Gene Involvement in Normal Hematopoiesis and in the Pathogenesis of Childhood Leukemias
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 3-4
Vassilis Zoumpourlis, Ioannis Christodoulou, Maria Adamaki, Maria Goulielmaki, Spiros Vlahopoulos
Commentary on Lynch Syndrome and Related Familial Colorectal Cancers
Critical Reviews™ in Oncogenesis, Vol.14, 2008, issue 1
Stephen J. Lanspa, Henry T. Lynch
Yin Yang I as an Epimodulator of miRNAs in the Metastatic Cascade
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Roberta Miceli, Amelia Cimmino, Gianluca Colella, Filomena de Nigris, Mariano Giuseppe Di Salvatore, Flavio Fazioli, Michele Gallo, Carlo Ruosi
Pediatric Brain Tumors: Genomics and Epigenomics Pave the Way
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 3-4
Adam M. Fontebasso , Nada Jabado