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Critical Reviews™ in Oncogenesis

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v12.i1-2.20
pages 3-26

Metaplasia — A Transdifferentiatlon Process that Facilitates Cancer Development: The Model of Gastric Intestinal Metaplasia

Patricia Mesquita
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, and the Medical Faculty of the University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal
Raquel Almeida
Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal
Nuno Lunet
Department of Hygiene and Epidemiology, Medical Faculty, University of Porto, 4200 Porto, Portugal
Celso A. Reis
Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal
Luis Filipe Santos Silva
Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal
Jacinta Serpa
Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal
Isabelle Van Seuningen
Inserm, U837, Centre de Recherche Jean-Pierre Aubert, France
Henrique Barros
Department of Hygiene and Epidemiology, Medical Faculty, University of Porto, 4200 Porto, Portugal
Leonor David
IPATIMUP

ABSTRACT

Metaplasia, in general, and intestinal metaplasia, in particular, are transdifferentiation processes triggered by environmental aggressions. The heterogeneity of different morphologic variants of metaplasia and distinction from close morphologic entities—heterotopia and hamartoma—is reviewed. Recent data on the characterization of the molecular and epidemiological data involved in the development and progression of lesions of gastric intestinal metaplasia are discussed. A redefinition of intestinal metaplasia is proposed.