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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v12.i1-2.30
pages 27-39

Sessile Serrated Adenoma: A Brief History and Current Status

Emina Emilia Torlakovic
Department of Pathology, College of Medicine, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK, S7N 0W8, Canada
Dale C. Snover
Department of Pathology, Fairview Southdale Hospital, 6401 France Ave. South, Edina, MN 55435


Sessile serrated adenoma (SSA) is a polyp of the large intestine, which was first described in 1996. It presents as a solitary lesion or in a setting of a polyposis previously coined as "serrated adenomatous polyposis." The importance of correct recognition of this lesion and distinction from other serrated polyps of the colon is in that the newly described "serrated pathway" of colorectal carcinogenesis seems to apply mostly to SSA and not to other serrated polyps of the colon. This review describes the history of morphologic discovery of SSA and reports on current status of this lesion.

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