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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Familial Breast Cancer, Underlying Genes, and Clinical Implications: A Review

Volume 12, Issue 1-2, 2006, pp. 75-113
DOI: 10.1615/CritRevOncog.v12.i1-2.50
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ABSTRACT

Family history has been a recognized risk factor for breast cancer for many years. We will, in this review, describe the research field in breast cancer susceptibility from the early epidemiological, loss of heterozygosity (LOH), and linkage studies in the 1990s leading to the discovery of BRCA1 and 2, and the subsequent search for other high- and low-risk genes at present. We will also describe the clinical implications of BRCA1 and 2. Finally, we will give a review of the field but also focus on our own research, molecular and clinical.

CITED BY
  1. Gilbert Penney M., Mouw Janna K., Unger Meredith A., Lakins Johnathon N., Gbegnon Mawuse K., Clemmer Virginia B., Benezra Miriam, Licht Jonathan D., Boudreau Nancy J., Tsai Kelvin K.C., Welm Alana L., Feldman Michael D., Weber Barbara L., Weaver Valerie M., HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype, Journal of Clinical Investigation, 120, 5, 2010. Crossref

  2. Aubé Michel, Larochelle Christian, Ayotte Pierre, Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines, Environmental Research, 111, 3, 2011. Crossref

  3. Paulinelli Régis Resende, Freitas-Junior Ruffo, de Lucena Clécio Ênio Murta, Moreira Marise Amaral Rebouças, de Moraes Vardeli Alves, Bernardes-Júnior Júlio Roberto Macedo, da Silva Rocha Vidal Célio, Ruiz Alessandro Naldi, Lucato Miliana Tostes, da Costa Nayara Gomes Silveira, Teixeira Danilo Augusto, Sonobreast: Predicting Individualized Probabilities of Malignancy in Solid Breast Masses with Echographic Expression, The Breast Journal, 17, 2, 2011. Crossref

  4. Briedienė Rūta, Grigienė R., Gudabskaitė Asta, SU BRCA 1 IR 2 MUTACIJOMIS SUSIJUSIO KRŪTIES VĖŽIO RADIOLOGINIAI IR MORFOLOGINIAI POŽYMIAI: TRUMPA LITERATŪROS APŽVALGA IR PATIRTIS NVI, Medicinos teorija ir praktika, 21, 4.1, 2015. Crossref

  5. Norberto Sónia, Calhau Conceição, Pestana Diogo, Faria Ana, Effects of Environmental Pollutants on MCF-7 Cells: A Metabolic Approach, Journal of Cellular Biochemistry, 118, 2, 2017. Crossref

  6. Mišík M., Nersesyan A., Parzefall W., Knasmüller S., Carcinogens in Foods, in Epigenetics and Human Health, 2010. Crossref

  7. Palmero Edenir I., Caleffi Maira, Schüler-Faccini Lavínia, Roth Fernanda L., Kalakun Luciane, Netto Cristina Brinkmann Oliveira, Skonieski Giovana, Giacomazzi Juliana, Weber Bernadete, Giugliani Roberto, Camey Suzi A., Ashton-Prolla Patricia, Population prevalence of hereditary breast cancer phenotypes and implementation of a genetic cancer risk assessment program in southern Brazil, Genetics and Molecular Biology, 32, 3, 2009. Crossref

  8. Wagner Belinda J., Presnell Sharon C., Loss of Heterozygosity, in Basic Concepts of Molecular Pathology, 2, 2009. Crossref

  9. Konda Manojna, Verma Rashmi, Cancer screening and prevention: Sex and gender evidence in lung, breast, and colorectal cancer, in How Sex and Gender Impact Clinical Practice, 2021. Crossref

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