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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2018026308
pages 69-92

Individual Response to Ionizing Radiation and Personalized Radiotherapy

Emiliya A. Domina
Department of Biological Effects of Ionizing and Non-Ionizing Radiation, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Alex Philchenkov
Department of Oncohematology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Anna Dubrovska
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology-OncoRay, Dresden, Germany; German Cancer Consortium (DKTK), partner site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany

ABSTRACT

Radiation therapy remains one of the most effective cancer treatments. Nevertheless, biology-driven personalized radiation therapy that enables treatment according to the biological characteristics of the individual tumors and normal tissues still needs to be implemented in the clinic. Understanding the mechanisms of radiation response in both tumors and normal tissues is necessary to develop reliable predictive biomarkers for tumor radioresistance and normal tissue toxicity as well as to exploit new therapeutic opportunities for tumor radiosensitization. In this article, we review the mechanisms of tumor radiosensitivity as well as the early and late responses of normal tissues to therapeutic radiation exposure. We also discuss the possible implementation of these mechanisms for biology-driven personalized radiation treatment.


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