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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Efficacy of Ghrelin in Cancer Cachexia: Clinical Trials and a Novel Treatment by Rikkunshito

Volume 17, Issue 3, 2012, pp. 277-284
DOI: 10.1615/CritRevOncog.v17.i3.50
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ABSTRACT

Cachexia is characterized by decreased food intake, increased energy expenditure, and muscle wasting. It is observed in 80% of patients with advanced-stage cancer and is a major source of decreased quality of life and increased morbidity and mortality in cancer patients. Ghrelin plays an important role in stimulating hunger and maintaining energy homeostasis and is the first-line treatment option for cancer cachexia. Several studies in rodent models and clinical trials have demonstrated that ghrelin or ghrelin receptor (GHS-R) agonists are effective in the treatment of cancer cachexia; however, further large-scale long-term clinical trials are needed to confirm sustained effects. Recently, the traditional Japanese medicine rikkunshito has been shown to increase food intake in rats with cancer or administered chemotherapeutics. The orexigenic effect of rikkunshito is involved in the stimulation of endogenous ghrelin secretion by blocking the serotonin (5-HT) 2b/2c receptor pathway and the enhancement of GHS-R activity. A potentiator of ghrelin signaling such as rikkunshito may represent a novel approach for the treatment of cancer cachexia.

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  13. Song Ying‐Chyi, Hung Kuo‐Feng, Liang Kai‐Li, Chiang Jen‐Huai, Huang Hui‐Chi, Lee Hui‐Ju, Wu Mei‐Yao, Yu Sheng‐Jie, Lo Hsin‐Yi, Ho Tin‐Yun, Yen Hung‐Rong, Adjunctive Chinese herbal medicine therapy for nasopharyngeal carcinoma: Clinical evidence and experimental validation, Head & Neck, 41, 9, 2019. Crossref

  14. Ye Nan, Yang Yifeng, Ma Zhongping, Huang Jian, Ghrelin promotes the osteogenic differentiation of rMSCs via miR-206 and the ERK1/2 pathway, Cytotechnology, 72, 5, 2020. Crossref

  15. Yamada Chihiro, Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease, International Journal of Molecular Sciences, 22, 7, 2021. Crossref

  16. Hung Kuo-Feng, Hsu Ching-Ping, Chiang Jen-Huai, Lin Hung-Jen, Kuo Yi-Ting, Sun Mao-Feng, Yen Hung-Rong, Complementary Chinese herbal medicine therapy improves survival of patients with gastric cancer in Taiwan: A nationwide retrospective matched-cohort study, Journal of Ethnopharmacology, 199, 2017. Crossref

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