Published 4 issues per year
ISSN Print: 0893-9675
ISSN Online: 2162-6448
Indexed in
Nitric Oxide and PGE-2 Cross-Talk in EGFR-Driven Epithelial Tumor Cells
ABSTRACT
Nitric oxide (NO) exerts physiopathological effects based mainly on its concentration. Thus, it facilitates or inhibits cancer-promoting characteristics. This review discusses the role of NO and its network of partners in tumor progression and angiogenesis: prostaglandin E 2 (PGE-2) and its producing enzymes, cyclooxigenase 2 (COX-2) and microsomal PGE synthase 1 (mPGES-1), and epidermal growth factor receptor (EGFR) signaling. Understanding the molecular mechanisms and cross-talk modulating NO effects by PGE-2 and EGFR and vice versa allows us to develop better therapeutic strategies for cancer treatment.
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Pizzinat Nathalie, Ong-Meang Varravaddheay, Bourgailh-Tortosa Florence, Blanzat Muriel, Perquis Lucie, Cussac Daniel, Parini Angelo, Poinsot Verena, Extracellular vesicles of MSCs and cardiomyoblasts are vehicles for lipid mediators, Biochimie, 178, 2020. Crossref