Library Subscription: Guest
Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Tumor Suppressor Roles of the Denitrosylase GSNOR

Volume 21, Issue 5-6, 2016, pp. 433-445
DOI: 10.1615/CritRevOncog.2017021074
Get accessGet access

ABSTRACT

Nitric oxide (NO) is a gaseous pleiotropic molecule that can both induce irreversible oxidative damages and modulate physiological signal transductions by transient protein modifications, the most important of which is the S-nitrosylation of cysteine residues. Being noxious and healthy, the role of NO in cancer is seemingly contradictory, as at low concentrations it mediates tumor growth and proliferation whereas at high concentrations it promotes apoptosis and cancer growth inhibition. However, it is becoming evident that when endogenously produced, such as upon inducible nitric oxide synthase (NOS) activation, NO acts to sustain tumorigenesis. Similarly, although less explored, defects and deficiency in the denitrosylating enzyme S-nitrosoglutathione reductase (GSNOR) have been associated with the development and malignancy of liver and breast cancers, suggesting a primary role for NO signaling−that is, S-nitrosylation, being deeply involved in neoplastic transformation and progression. In this review, we summarize past and recent evidence on the role of S-nitrosylation and GSNOR in different processes that contribute to cell transformation when deregulated, such as DNA damage repair, energetic metabolism, and cell death. We also outline possible S-nitrosylation–targeted proteins that might contribute to tumorigenesis, and, finally, we speculate on the role of GSNOR in regulating the oncogenic effects induced downstream.

CITED BY
  1. Rizza Salvatore, Filomeni Giuseppe, Role, Targets and Regulation of (de)nitrosylation in Malignancy, Frontiers in Oncology, 8, 2018. Crossref

  2. Bignon Emmanuelle, Allega Maria Francesca, Lucchetta Marta, Tiberti Matteo, Papaleo Elena, Computational Structural Biology of S-nitrosylation of Cancer Targets, Frontiers in Oncology, 8, 2018. Crossref

  3. Rizza Salvatore, Giglio Paola, Faienza Fiorella, Filomeni Giuseppe, Therapeutic Aspects of Protein Denitrosylation, in Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders, 2019. Crossref

  4. Montagna Costanza, Cirotti Claudia, Rizza Salvatore, Filomeni Giuseppe, When S-Nitrosylation Gets to Mitochondria: From Signaling to Age-Related Diseases, Antioxidants & Redox Signaling, 32, 12, 2020. Crossref

  5. Faienza Fiorella, Rizza Salvatore, Giglio Paola, Filomeni Giuseppe, TRAP1: A Metabolic Hub Linking Aging Pathophysiology to Mitochondrial S-Nitrosylation, Frontiers in Physiology, 11, 2020. Crossref

  6. Chatterji Ajanta, Sengupta Rajib, Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation, The International Journal of Biochemistry & Cell Biology, 131, 2021. Crossref

  7. Salvatori Luisa, Spallotta Francesco, Gaetano Carlo, Illi Barbara, Pillars and Gaps of S-Nitrosylation-Dependent Epigenetic Regulation in Physiology and Cancer, Life, 11, 12, 2021. Crossref

  8. Niu Ying‐Jie, Zhou Dongjie, Cui Xiang‐Shun, S‐nitrosoglutathione reductase maintains mitochondrial homeostasis by promoting clearance of damaged mitochondria in porcine preimplantation embryos, Cell Proliferation, 54, 3, 2021. Crossref

  9. Rizza Salvatore, Filomeni Giuseppe, Exploiting S-nitrosylation for cancer therapy: facts and perspectives, Biochemical Journal, 477, 19, 2020. Crossref

  10. Rizza Salvatore, Di Leo Luca, Mandatori Sara, De Zio Daniela, Filomeni Giuseppe, Mitophagy contributes to alpha-tocopheryl succinate toxicity in GSNOR-deficient hepatocellular carcinoma, Biochemical Pharmacology, 176, 2020. Crossref

  11. Montagna Costanza, Filomeni Giuseppe, Looking at denitrosylation to understand the myogenesis gone awry theory of rhabdomyosarcoma, Nitric Oxide, 122-123, 2022. Crossref

  12. Dios-Barbeito Sandra, González Raúl, Cadenas Miryam, García Lisander F., Victor Victor M., Padillo Francisco J., Muntané Jordi, Impact of nitric oxide in liver cancer microenvironment, Nitric Oxide, 128, 2022. Crossref

  13. Bhattacharyya Camelia, Chakraborty Surupa, Sengupta Rajib, NO news: S-(de)nitrosylation of cathepsins and their relationship with cancer, Analytical Biochemistry, 655, 2022. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain